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1
Isolation of a pdxJ point mutation that bypasses the requirement for the PdxH oxidase in pyridoxal 5' -phosphate coenzyme biosynthesis in Escherichia coli K-12.在大肠杆菌K-12中分离出一种pdxJ点突变，该突变绕过了磷酸吡哆醛辅酶生物合成中对PdxH氧化酶的需求。
J Bacteriol. 1996 Apr;178(8):2445-9. doi: 10.1128/jb.178.8.2445-2449.1996.
2
Suppression of insertions in the complex pdxJ operon of Escherichia coli K-12 by lon and other mutations.lon及其他突变对大肠杆菌K-12复合pdxJ操纵子中插入序列的抑制作用。
J Bacteriol. 1992 Mar;174(5):1554-67. doi: 10.1128/jb.174.5.1554-1567.1992.
3
Characterization of the complex pdxH-tyrS operon of Escherichia coli K-12 and pleiotropic phenotypes caused by pdxH insertion mutations.大肠杆菌K-12复合pdxH-tyrS操纵子的特征以及由pdxH插入突变引起的多效性表型
J Bacteriol. 1992 Oct;174(19):6033-45. doi: 10.1128/jb.174.19.6033-6045.1992.
4
Phylogenetic analyses and comparative genomics of vitamin B6 (pyridoxine) and pyridoxal phosphate biosynthesis pathways.维生素B6（吡哆醇）和磷酸吡哆醛生物合成途径的系统发育分析与比较基因组学
J Mol Microbiol Biotechnol. 2001 Jan;3(1):1-20.
5
Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein.维生素B6生物合成：PdxA和PdxJ蛋白从4-（磷酸羟基）-L-苏氨酸和1-脱氧-D-木酮糖-5-磷酸形成5'-磷酸吡哆醇。
FEBS Lett. 1999 Apr 16;449(1):45-8. doi: 10.1016/s0014-5793(99)00393-2.
6
Purification and characterization of the pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating) from Escherichia coli.来自大肠杆菌的磷酸吡哆醛-5'-磷酸：氧氧化还原酶（脱氨基）的纯化与特性分析
Biochim Biophys Acta. 1995 Mar 15;1247(2):265-71. doi: 10.1016/0167-4838(94)00235-9.
7
Kinetic limitation and cellular amount of pyridoxine (pyridoxamine) 5'-phosphate oxidase of Escherichia coli K-12.大肠杆菌K-12中吡哆醇（吡哆胺）5'-磷酸氧化酶的动力学限制和细胞数量
J Bacteriol. 1995 Feb;177(4):883-91. doi: 10.1128/jb.177.4.883-891.1995.
8
Crystallization and preliminary X-ray crystallographic analysis of PdxJ, the pyridoxine 5'-phosphate synthesizing enzyme.吡哆醇5'-磷酸合成酶PdxJ的结晶及初步X射线晶体学分析
Acta Crystallogr D Biol Crystallogr. 2000 Aug;56(Pt 8):1045-8. doi: 10.1107/s0907444900007368.
9
PdxH proteins of mycobacteria are typical members of the classical pyridoxine/pyridoxamine 5'-phosphate oxidase family.分枝杆菌的PdxH蛋白是经典的吡哆醇/吡哆胺5'-磷酸氧化酶家族的典型成员。
FEBS Lett. 2016 Feb;590(4):453-60. doi: 10.1002/1873-3468.12080. Epub 2016 Feb 15.
10
X-ray structure of Escherichia coli pyridoxine 5'-phosphate oxidase complexed with pyridoxal 5'-phosphate at 2.0 A resolution.大肠杆菌5'-磷酸吡哆醛氧化酶与5'-磷酸吡哆醛复合物在2.0埃分辨率下的X射线结构。
J Mol Biol. 2001 Jul 20;310(4):817-26. doi: 10.1006/jmbi.2001.4734.

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1
Vitamer levels, stress response, enzyme activity, and gene regulation of Arabidopsis lines mutant in the pyridoxine/pyridoxamine 5'-phosphate oxidase (PDX3) and the pyridoxal kinase (SOS4) genes involved in the vitamin B6 salvage pathway.参与维生素B6补救途径的吡哆醇/吡哆胺5'-磷酸氧化酶（PDX3）和吡哆醛激酶（SOS4）基因发生突变的拟南芥株系的维生素原水平、应激反应、酶活性和基因调控。
Plant Physiol. 2007 Nov;145(3):985-96. doi: 10.1104/pp.107.105189. Epub 2007 Sep 14.
2
Positive growth rate-dependent regulation of the pdxA, ksgA, and pdxB genes of Escherichia coli K-12.大肠杆菌K-12的pdxA、ksgA和pdxB基因的正生长速率依赖性调控。
J Bacteriol. 2002 Mar;184(5):1359-69. doi: 10.1128/JB.184.5.1359-1369.2002.
3
Identification and function of the pdxY gene, which encodes a novel pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate biosynthesis in Escherichia coli K-12.pdxY基因的鉴定与功能，该基因编码一种新型吡哆醛激酶，参与大肠杆菌K-12中5'-磷酸吡哆醛生物合成的补救途径。
J Bacteriol. 1998 Apr;180(7):1814-21. doi: 10.1128/JB.180.7.1814-1821.1998.
4
The apbE gene encodes a lipoprotein involved in thiamine synthesis in Salmonella typhimurium.apbE基因编码一种参与鼠伤寒沙门氏菌硫胺素合成的脂蛋白。
J Bacteriol. 1998 Feb;180(4):885-91. doi: 10.1128/JB.180.4.885-891.1998.
5
Maximization of transcription of the serC (pdxF)-aroA multifunctional operon by antagonistic effects of the cyclic AMP (cAMP) receptor protein-cAMP complex and Lrp global regulators of Escherichia coli K-12.环腺苷酸（cAMP）受体蛋白-cAMP复合物与大肠杆菌K-12的全局调控因子Lrp的拮抗作用使serC（pdxF）-aroA多功能操纵子的转录最大化。
J Bacteriol. 1997 Jun;179(11):3458-69. doi: 10.1128/jb.179.11.3458-3469.1997.

本文引用的文献

1
Synthesis of Pyridoxine by a Pyridoxal Auxotroph of Escherichia coli.大肠杆菌吡哆醛营养缺陷型菌株合成吡哆醇
J Bacteriol. 1966 Aug;92(2):333-7. doi: 10.1128/jb.92.2.333-337.1966.
2
Pyridoxamine phosphate-oxidase and pyridoxal phosphate-phosphatase activities in Escherichia coli.大肠杆菌中磷酸吡哆胺氧化酶和磷酸吡哆醛磷酸酶的活性
Biochem J. 1961 Feb;78(2):364-72. doi: 10.1042/bj0780364.
3
4-Phospho-hydroxy-L-threonine is an obligatory intermediate in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12.4-磷酸羟基-L-苏氨酸是大肠杆菌K-12中磷酸吡哆醛辅酶生物合成的必需中间体。
FEMS Microbiol Lett. 1996 Jan 15;135(2-3):275-80. doi: 10.1111/j.1574-6968.1996.tb08001.x.
4
Growth response to 4-hydroxy-L-threonine of Escherichia coli mutants blocked in vitamin B6 biosynthesis.维生素B6生物合成受阻的大肠杆菌突变体对4-羟基-L-苏氨酸的生长反应。
FEBS Lett. 1993 Mar 1;318(2):125-8. doi: 10.1016/0014-5793(93)80005-f.
5
Cloning, DNA sequence, and complementation analysis of the Salmonella typhimurium hemN gene encoding a putative oxygen-independent coproporphyrinogen III oxidase.鼠伤寒沙门氏菌hemN基因的克隆、DNA序列及互补分析，该基因编码一种假定的不依赖氧气的粪卟啉原III氧化酶。
J Bacteriol. 1994 Jun;176(11):3196-203. doi: 10.1128/jb.176.11.3196-3203.1994.
6
Characterization of broadly pleiotropic phenotypes caused by an hfq insertion mutation in Escherichia coli K-12.大肠杆菌K-12中hfq插入突变引起的广泛多效性表型的特征分析
Mol Microbiol. 1994 Jul;13(1):35-49. doi: 10.1111/j.1365-2958.1994.tb00400.x.
7
An Escherichia coli K-12 tktA tktB mutant deficient in transketolase activity requires pyridoxine (vitamin B6) as well as the aromatic amino acids and vitamins for growth.一种缺乏转酮醇酶活性的大肠杆菌K-12 tktA tktB突变体生长需要吡哆醇（维生素B6）以及芳香族氨基酸和维生素。
J Bacteriol. 1994 Oct;176(19):6134-8. doi: 10.1128/jb.176.19.6134-6138.1994.
8
Kinetic limitation and cellular amount of pyridoxine (pyridoxamine) 5'-phosphate oxidase of Escherichia coli K-12.大肠杆菌K-12中吡哆醇（吡哆胺）5'-磷酸氧化酶的动力学限制和细胞数量
J Bacteriol. 1995 Feb;177(4):883-91. doi: 10.1128/jb.177.4.883-891.1995.
9
Cloning and characterization of the Escherichia coli hemN gene encoding the oxygen-independent coproporphyrinogen III oxidase.编码不依赖氧气的粪卟啉原III氧化酶的大肠杆菌hemN基因的克隆与特性分析。
J Bacteriol. 1995 Jun;177(11):3326-31. doi: 10.1128/jb.177.11.3326-3331.1995.
10
Biochemical characterization of gapB-encoded erythrose 4-phosphate dehydrogenase of Escherichia coli K-12 and its possible role in pyridoxal 5'-phosphate biosynthesis.大肠杆菌K-12中gapB编码的4-磷酸赤藓糖脱氢酶的生化特性及其在5'-磷酸吡哆醛生物合成中的可能作用。
J Bacteriol. 1995 May;177(10):2804-12. doi: 10.1128/jb.177.10.2804-2812.1995.

在大肠杆菌K-12中分离出一种pdxJ点突变，该突变绕过了磷酸吡哆醛辅酶生物合成中对PdxH氧化酶的需求。

Isolation of a pdxJ point mutation that bypasses the requirement for the PdxH oxidase in pyridoxal 5' -phosphate coenzyme biosynthesis in Escherichia coli K-12.

作者信息

Man T K, Zhao G, Winkler M E

机构信息

Department of Microbiology and Molecular Genetics, University of Texas Houston Medical School 77030-1501, USA.

出版信息

J Bacteriol. 1996 Apr;178(8):2445-9. doi: 10.1128/jb.178.8.2445-2449.1996.

DOI:10.1128/jb.178.8.2445-2449.1996
PMID:8636054
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC177961/
Abstract

We isolated 26 suppressor mutations that allowed growth of a delta pdxH::omega null mutant in the absence of pyridoxal. Each suppressor mapped to pdxJ, and the eight suppressors sequenced contained the same glycine-to-serine change in the PdxJ polypeptide. This bypass suppression suggests that PdxJ may participate in formation of the pyridine ring of pyridoxine 5'-phosphate.

摘要

我们分离出了26个抑制突变，这些突变使得ΔpdxH::omega缺失突变体在没有吡哆醛的情况下能够生长。每个抑制突变都定位到pdxJ，并且测序的8个抑制突变在PdxJ多肽中包含相同的甘氨酸到丝氨酸的变化。这种旁路抑制表明PdxJ可能参与磷酸吡哆醛吡啶环的形成。