Martinez C R, Fara J W, Donner M W
Invest Radiol. 1979 Sep-Oct;14(5):428-31. doi: 10.1097/00004424-197909000-00008.
Experiments were done to test the hypothesis that emptying the gallbladder prior to intravenous cholangiography (IVC) would result in earler and better opacification of the gallbladder. Five dogs were studied on two separate days in a crossover experiment. Each dog had a standard IVC (15-minute infusion of meglumine iodipamide) 2.5 cc/kg of following a 14-16-hour fasting period. On one of the days, 0.3 mcg/kg of Ceruletide was intramuscularly administered to each dog 30 to 45 minutes prior to the iodipamide infusion. Films obtained at the end of infusion and at 20, 40, 60, and 90 minutes were evaluated independently by three radiologists. The results indicate that pretreatment with Ceruletide produces a significant (p less than 0.05) improvement in the quality of gallbladder opacification during the first 90 minutes following iodipamide infusion. We conclude that earlier and better opacification of the gallbladder during IVC can be obtained by prior emptying of the gallbladder with a cholecystokinetic agent.
在静脉胆管造影（IVC）前排空胆囊会使胆囊更早且更清晰地显影。在一项交叉实验中，对五只狗在两个不同日期进行了研究。每只狗在禁食14 - 16小时后接受标准IVC（静脉注射2.5 cc/kg的碘番酸葡甲胺，输注15分钟）。在其中一天，在输注碘番酸葡甲胺前30至45分钟，给每只狗肌肉注射0.3 mcg/kg的赛鲁肽。由三位放射科医生独立评估在输注结束时以及20、40、60和90分钟时获得的X光片。结果表明，用赛鲁肽预处理在输注碘番酸葡甲胺后的前90分钟内，胆囊显影质量有显著改善（p小于0.05）。我们得出结论，在IVC期间，通过使用胆囊收缩剂预先排空胆囊，可以使胆囊更早且更清晰地显影。
