Kazmers A, Jacobs L, Perkins A, Lindenauer S M, Bates E
Ann Arbor Health Services Research & Development, Department of Veterans Affairs, Ann Arbor, Mich., USA.
J Vasc Surg. 1996 Feb;23(2):191-200. doi: 10.1016/s0741-5214(96)70263-x.
This study was performed to define outcomes after abdominal aortic aneurysm (AAA) repair in Veterans Affairs (VA) medical centers during fiscal years 1991 through 1993.
With VA patient treatment file data, patients were selected from diagnosis-related groups 110 and 111 and were then classified in a patient management category. In the categories of repair of nonruptured and ruptured AAA, mortality and postoperative complication rates were defined for patients who underwent AAA repair in VA medical centers during the 3-year study period.
Hospital mortality rates were 4.86% (166 of 3419) after repair of nonruptured AAA and 47.0% (126 of 268) after repair of ruptured AAA (p<0.001). Of 292 deaths after AAA repair, 136 (43.2%) followed repair of ruptured AAA, even though ruptured AAA comprised only 7.3% of total AAA surgical volume. AAA repairs were performed at 116 VA medical centers, with 31.8+/-23.1 (range, 1 to 140) procedures performed at each center. Although many lower-volume centers had excellent results, centers that performed >or=32 AAA repairs tended to have lower in-hospital mortality rates after repair of nonruptured AAA than those that performed <or=31 procedures (4.2%+/-3.5% compared with 6.7%+/-7.8%;p<0.05). Poisson regression analysis revealed an inverse relationship between the volume of AAA repairs and individual hospital mortality (p=0.001) and a direct relationship between illness severity and hospital mortality (p=0.008). The proportion of ruptured AAAs treated in a hospital was also directly related to individual hospital mortality rates (p<0.005). Postoperative complications were associated with an increased hospital mortality rate (11.7% with complication compared with 6.5% without; p<0.0001) and length of stay (23.6+/-17.1 days compared with 18.0+/-12.4 days; p<0.0001). In a logistic regression model, increased mortality rates after AAA repair were associated with hospital type (adjusted odds ratio [OR]=0.6), increasing age (OR=1.1), patient management category severity score (OR=2.2), hemorrhage (OR=2.3), myocardial infarction (OR=2.6), disseminated intravascular coagulation (OR=4.7), AAA rupture (OR=6.0), postoperative shock (OR=10.7), cardiopulmonary arrest (OR=15.4), central nervous system complications (OR=16.0) and urologic complications (OR=2.4).
Mortality rates after AAA repair in VA hospitals were comparable with those previously reported in other large series. Outcomes for veterans with AAA may improve by referring patients eligible for elective repair to VA medical centers with a greater operative volume or to lower-volume centers that have had excellent results.
本研究旨在明确1991财年至1993财年期间退伍军人事务部(VA)医疗中心腹主动脉瘤(AAA)修复术后的结果。
利用VA患者治疗档案数据,从诊断相关组110和111中选取患者,然后将其分类到患者管理类别中。在未破裂和破裂AAA修复类别中,确定了在3年研究期间于VA医疗中心接受AAA修复的患者的死亡率和术后并发症发生率。
未破裂AAA修复术后医院死亡率为4.86%(3419例中的166例),破裂AAA修复术后为47.0%(268例中的126例)(p<0.001)。在AAA修复术后的292例死亡病例中,136例(43.2%)发生在破裂AAA修复后,尽管破裂AAA仅占AAA手术总量的7.3%。在116个VA医疗中心进行了AAA修复,每个中心进行了31.8±23.1(范围为1至140)例手术。尽管许多手术量较低的中心效果良好,但进行≥32例AAA修复的中心在未破裂AAA修复术后的院内死亡率往往低于进行≤31例手术的中心(4.2%±3.5%与6.7%±7.8%相比;p<0.05)。泊松回归分析显示,AAA修复手术量与个体医院死亡率呈负相关(p=0.001),疾病严重程度与医院死亡率呈正相关(p=0.008)。医院中治疗破裂AAA的比例也与个体医院死亡率直接相关(p<0.005)。术后并发症与医院死亡率增加(有并发症者为11.7%,无并发症者为6.5%;p<0.0001)和住院时间延长(23.6±17.1天与18.0±12.4天相比;p<0.0001)相关。在逻辑回归模型中,AAA修复术后死亡率增加与医院类型(调整后的优势比[OR]=0.6)、年龄增加(OR=1.1)、患者管理类别严重程度评分(OR=2.2)、出血(OR=2.3)心肌梗死(OR=2.6)、弥散性血管内凝血(OR=4.7)、AAA破裂(OR=6.0)、术后休克(OR=10.7)、心肺骤停(OR=15.4)、中枢神经系统并发症(OR=16.0)和泌尿系统并发症(OR=2.4)有关。
VA医院AAA修复术后的死亡率与先前其他大型系列报道的死亡率相当。对于符合择期修复条件的退伍军人患者,将其转诊至手术量较大的VA医疗中心或效果良好的低手术量中心,AAA患者的治疗结果可能会得到改善。