Bhasin S, Storer T W, Berman N, Callegari C, Clevenger B, Phillips J, Bunnell T J, Tricker R, Shirazi A, Casaburi R
Department of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.
N Engl J Med. 1996 Jul 4;335(1):1-7. doi: 10.1056/NEJM199607043350101.
Athletes often take androgenic steroids in an attempt to increase their strength. The efficacy of these substances for this purpose is unsubstantiated, however.
We randomly assigned 43 normal men to one of four groups: placebo with no exercise; testosterone with no exercise; placebo plus exercise; and testosterone plus exercise. The men received injections of 600 mg of testosterone enanthate or placebo weekly for 10 weeks. The men in the exercise groups performed standardized weight-lifting exercises three times weekly. Before and after the treatment period, fat-free mass was determined by underwater weighing, muscle size was measured by magnetic resonance imaging, and the strength of the arms and legs was assessed by bench-press and squatting exercises, respectively.
Among the men in the no-exercise groups, those given testosterone had greater increases than those given placebo in muscle size in their arms (mean [+/-SE] change in triceps area, 424 +/- 104 vs. -81 +/- 109 square millimeters; P < 0.05) and legs (change in quadriceps area, 607 +/- 123 vs. -131 +/- 111 square millimeters; P < 0.05) and greater increases in strength in the bench-press (9 +/- 4 vs. -1 +/- 1 kg, P < 0.05) and squatting exercises (16 +/- 4 vs. 3 +/- 1 kg, P < 0.05). The men assigned to testosterone and exercise had greater increases in fat-free mass (6.1 +/- 0.6 kg) and muscle size (triceps area, 501 +/- 104 square millimeters; quadriceps area, 1174 +/- 91 square millimeters) than those assigned to either no-exercise group, and greater increases in muscle strength (bench-press strength, 22 +/- 2 kg; squatting-exercise capacity, 38 +/- 4 kg) than either no-exercise group. Neither mood nor behavior was altered in any group.
Supraphysiologic doses of testosterone, especially when combined with strength training, increase fat-free mass and muscle size and strength in normal men.
运动员常服用雄激素类固醇以期增强力量。然而，这些物质用于此目的的疗效尚无确凿证据。
我们将43名正常男性随机分为四组之一：不运动服用安慰剂组；不运动服用睾酮组；运动加安慰剂组；运动加睾酮组。这些男性每周接受一次600毫克庚酸睾酮或安慰剂注射，共10周。运动组的男性每周进行三次标准化举重运动。在治疗期前后，通过水下称重测定去脂体重，通过磁共振成像测量肌肉大小，分别通过卧推和深蹲运动评估手臂和腿部力量。
在不运动组中，服用睾酮的男性手臂肌肉大小（肱三头肌面积的平均[±标准误]变化，424±104对-8Ⅰ±109平方毫米；P<0.05）和腿部肌肉大小（股四头肌面积变化，607±123对-13Ⅰ±111平方毫米；P<0.05）的增加幅度大于服用安慰剂的男性，卧推力量（9±4对-Ⅰ±Ⅰ千克，P<0.05）和深蹲运动力量（16±4对3±Ⅰ千克,P<0.05）的增加幅度也更大。与不运动组相比，服用睾酮且运动的男性去脂体重（6.Ⅰ±0.6千克）和肌肉大小（肱三头肌面积，50Ⅰ±104平方毫米；股四头肌面积，1174±9Ⅰ平方毫米）增加幅度更大，肌肉力量（卧推力量，22±2千克；深蹲运动能力，38±4千克）增加幅度也大于任何一个不运动组。任何一组的情绪和行为均未改变。
超生理剂量的睾酮，尤其是与力量训练相结合时，可增加正常男性的去脂体重、肌肉大小和力量。
