D'Erchia A M, Gissi C, Pesole G, Saccone C, Arnason U
Dipartimento di Biochimica e Biología Molecolare, Università di Bari, Italy.
Nature. 1996 Jun 13;381(6583):597-600. doi: 10.1038/381597a0.
In 1991 Graur et al. raised the question of whether the guinea-pig, Cavia porcellus, is a rodent. They suggested that the guinea-pig and myomorph rodents diverged before the separation between myomorph rodents and a lineage leading to primates and artiodactyls. Several findings have since been reported, both for and against this phylogeny, thereby highlighting the issue of the validity of molecular analysis in mammalian phylogeny. Here we present findings based on the sequence of the complete mitochondrial genome of the guinea-pig, which strongly contradict rodent monophyly. The conclusions are based on cumulative evidence provided by orthologically inherited genes and the use of three different analytical methods, none of which joins the guinea-pig with myomorph rodents. In addition to the phylogenetic conclusions, we also draw attention to several factors that are important for the validity of phylogenetic analysis based on molecular data.
1991年，格劳尔等人提出了豚鼠（Cavia porcellus）是否属于啮齿动物的问题。他们认为，豚鼠与鼠形啮齿动物在鼠形啮齿动物与通向灵长类动物和偶蹄目动物的谱系分离之前就已经分化。此后，有几项支持和反对这种系统发育关系的研究结果被报道，从而凸显了分子分析在哺乳动物系统发育研究中有效性的问题。在此，我们展示了基于豚鼠完整线粒体基因组序列的研究结果，这些结果强烈反驳了啮齿动物单系性的观点。这些结论基于直系同源遗传基因提供的累积证据以及三种不同分析方法的使用，没有一种方法能将豚鼠与鼠形啮齿动物归为一类。除了系统发育结论外，我们还提请注意几个对基于分子数据的系统发育分析有效性很重要的因素。
