Bryan J P, Iqbal M, Ksiazek T G, Ahmed A, Duncan J F, Awan B, Krieg R E, Riaz M, Leduc J W, Nabi S, Qureshi M S, Malik I A, Legters L J
Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA.
Mil Med. 1996 Mar;161(3):149-53.
To determine the prevalence of antibodies to viral diseases known or suspected to be present in Pakistan, we studied 570 sera from three groups of adults; two of the groups were involved in outbreaks of hepatitis, and the third included men admitted to a hospital for evaluation of febrile illnesses. Immunoglobulin G antileptospiral antibody was found in 1 to 6% of the subjects, with the highest rate in enlisted military personnel hospitalized for febrile illness. One man in the group with febrile illness had significantly elevated immunoglobulin M antileptospiral antibody titers. However, in a group of recruits experiencing suspected non-A, non-B hepatitis, 19 (11%) of 173 had a 4-fold rise in immunoglobulin M antibody to leptospirosis. Antibody to sand fly fever viruses was found in 27 to 70%. Antibody to West Nile virus was present in 33 to 41% of subjects. Antibody reactive with Japanese encephalitis virus was present in 25%, but plaque reduction neutralization tests suggested this to be cross-reaction with West Nile virus. All 212 specimens tested for antibody to Crimean-Congo hemorrhagic fever and Hantaan viruses were negative. This study indicates that diseases known to be prevalent in other areas of southwest Asia and the Middle East are also prevalent in northern Pakistan and may impact on those traveling or working in this area.
为确定已知或疑似在巴基斯坦存在的病毒性疾病抗体的流行情况，我们研究了三组成年人的570份血清；其中两组涉及肝炎暴发，第三组包括因发热性疾病入院接受评估的男性。1%至6%的受试者中发现了免疫球蛋白G抗钩端螺旋体抗体，因发热性疾病住院的现役军人中该抗体的检出率最高。发热性疾病组中有一名男性的免疫球蛋白M抗钩端螺旋体抗体滴度显著升高。然而，在一组疑似非甲非乙型肝炎的新兵中，173人中有19人（11%）的钩端螺旋体免疫球蛋白M抗体升高了4倍。白蛉热病毒抗体的检出率为27%至70%。西尼罗河病毒抗体在33%至41%的受试者中存在。与日本脑炎病毒反应的抗体在25%的受试者中存在，但蚀斑减少中和试验表明这是与西尼罗河病毒的交叉反应。所有检测克里米亚-刚果出血热和汉坦病毒抗体的212份标本均为阴性。这项研究表明，在亚洲西南部和中东其他地区已知流行的疾病在巴基斯坦北部也很普遍，可能会对在该地区旅行或工作的人产生影响。
