Hiratsuka T, Abe M, Takehana K, Iwasa K, Hiraga T, Kobayashi A
Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.
Okajimas Folia Anat Jpn. 1996 Mar;72(6):285-95. doi: 10.2535/ofaj1936.72.6_285.
The distribution of endocrine cells and the areas of islets in the bovine pancreas were investigated by immunohistochemical methods. The islets in the A-region, which consisted of the left lobe, the ventral portion of the body, and the ventral and distal portions of the right lobe, contained a central core of insulin-containing (B-) cells surrounded by glucagon containing (A-) cells, a few somatostatin-containing (D-) cells and sporadic pancreatic polypeptide-containing (PP-) cells. The islets in the B-region, which consisted of the uncinate process, and the dorsal and proximal portions of the body and the right lobe, contained a central mass of B-cells, and peripheral cells which were predominantly PP-cells with a few D-cells but no A-cells. The areas of islets in the B-region were small as compared with those in the A-region. From these findings it is suggested that A- and PP-cells have a complementary relationship to one another. In view of this hypothesis, two types of islet, A-cell-rich and PP-cell-rich islets, were identified. The A-region contained A-cell-rich islets derived from the dorsal pancreatic primordium, while the B-region contained PP-cell-rich islets that originated from the ventral primordium. In the bovine pancreas, the areas containing PP-cell-rich islets are greater than those in previously examined species.
采用免疫组织化学方法研究了牛胰腺内分泌细胞的分布及胰岛区域。A区域的胰岛由左叶、胰体腹侧部分以及右叶腹侧和远端部分组成，其包含一个含胰岛素的（B）细胞中央核心，周围环绕着含胰高血糖素的（A）细胞、少量含生长抑素的（D）细胞和散在的含胰多肽的（PP）细胞。B区域的胰岛由钩突、胰体背侧和近端部分以及右叶组成，包含一个B细胞中央团块，周围细胞主要是PP细胞，有少量D细胞但无A细胞。与A区域相比，B区域的胰岛面积较小。从这些发现表明，A细胞和PP细胞彼此具有互补关系。基于这一假设，确定了两种类型的胰岛，即富含A细胞的胰岛和富含PP细胞的胰岛。A区域包含源自背侧胰腺原基的富含A细胞的胰岛，而B区域包含源自腹侧原基的富含PP细胞的胰岛。在牛胰腺中，富含PP细胞的胰岛区域比先前研究的物种更大。
