Muranishi T, Takehana K, Hiratsuka T, Kobayashi A, Iwasa K, Abe M
Department of Veterinary Anatomy, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
J Vet Med Sci. 1999 Jul;61(7):737-42. doi: 10.1292/jvms.61.737.
The pancreata of four six-month-old dogs of the same mother, two with both the pancreatic and accessory pancreatic ducts (X-type) and two with only the accessory pancreatic duct (Y-type), were examined in this study. To clarify the relationships between the type of pancreatic duct system and the composition of pancreatic endocrine cells, the pancreata were examined immunohistochemically using antiserum against four types of pancreatic hormones (glucagon, insulin, somatostatin and pancreatic polypeptide). In all areas of the X- and Y-type duct system pancreata, B cells accounted for 52-82% of the total number of islet cells, and D cells accounted for 4-15%. In the X-type ducts system, the percentages of A and PP cells in the right and left lobes of the pancreas differed greatly. It was found that A and PP cells appear in inverse proportion to each other and that there exist A cell-rich and PP cell-rich pancreatic islets. The A cell-rich pancreatic islets appeared in the left lobes along the accessory pancreatic duct, while the PP cell-rich pancreatic islets were observed in the right lobes along the pancreatic duct. The body of the pancreas contained both A cell-rich and PP cell-rich pancreatic islets. In the Y-type duct systems, A cell-rich pancreatic islets appeared in the right lobes. These findings indicate that the composition of A and PP cells in pancreatic islets is closely related to the type of duct system.
本研究检查了同一只母犬的4只6月龄幼犬的胰腺，其中2只具有主胰管和副胰管（X型），2只仅具有副胰管（Y型）。为了阐明胰管系统类型与胰腺内分泌细胞组成之间的关系，使用针对四种胰腺激素（胰高血糖素、胰岛素、生长抑素和胰多肽）的抗血清对胰腺进行免疫组织化学检查。在X型和Y型胰管系统胰腺的所有区域，B细胞占胰岛细胞总数的52%至82%，D细胞占4%至15%。在X型胰管系统中，胰腺左右叶中A细胞和PP细胞的百分比差异很大。发现A细胞和PP细胞呈反比出现，并且存在富含A细胞和富含PP细胞的胰岛。富含A细胞的胰岛出现在沿副胰管的左叶，而富含PP细胞的胰岛在沿主胰管的右叶中观察到。胰腺体部同时含有富含A细胞和富含PP细胞的胰岛。在Y型胰管系统中，富含A细胞的胰岛出现在右叶。这些发现表明胰岛中A细胞和PP细胞的组成与胰管系统类型密切相关。
