Bonneau R H, Mormède P, Vogler G P, McClearn G E, Jones B C
Department of Microbiology and Immunology, College of Medicine, Pennsylvania State University, Milton S. Hershey Medical Center, Hershey 17033, USA.
Brain Behav Immun. 1998 Jun;12(2):83-9. doi: 10.1006/brbi.1998.0523.
Psychoneuroimmunology is an exciting, complex field that elucidates interactions among the nervous, endocrine, and immune systems. The contribution of psychosocial factors and behavioral processes to these interactions has been the focus of numerous studies designed to investigate the intricate pathways that are involved in the "mind-body connection." In addition, the effects of this connection on the development and progression of various disease conditions are of considerable interest. Although efforts have been made to identify the cellular and molecular mechanisms underlying these relationships, the impact of genetic makeup on the communication among these systems has yet to be fully realized. The development of sophisticated genetic analytical methods and gene mapping techniques now provide the "tools" to determine the influence of genetics on behavior-neuroendocrine-immune interactions--an area of study that may represent the next frontier in psychoneuroimmunology.
心理神经免疫学是一个令人兴奋的复杂领域，它阐明了神经、内分泌和免疫系统之间的相互作用。心理社会因素和行为过程对这些相互作用的影响一直是众多研究的焦点，这些研究旨在探究参与“身心联系”的复杂途径。此外，这种联系对各种疾病状况的发生和发展的影响也备受关注。尽管人们已努力确定这些关系背后的细胞和分子机制，但基因构成对这些系统间通讯的影响尚未得到充分认识。先进的基因分析方法和基因图谱技术的发展，现在为确定遗传学对行为-神经内分泌-免疫相互作用的影响提供了“工具”——这一研究领域可能代表了心理神经免疫学的下一个前沿。
