Rosenthal R R, Norman P S, Summer W R, Permutt S
J Appl Physiol Respir Environ Exerc Physiol. 1977 Apr;42(4):600-6. doi: 10.1152/jappl.1977.42.4.600.
Human subjects, sensitive to ragweed, inhaled aerosols of increasing concentrations of ragweed pollen extract in the presence and absence of pretreatment with inhaled atropine. The cumulative dose of antigen required for a 35% decrease in airways conductance was termed PD35. Atropine, 1.2 or 5 mg, increased airways conductance before antigenic challenge but did not alter signigicantly the PD35 for ragweed extract, although these doses of atropine inhibited airways responses to inhaled methacholine chloride and citric acid. We conclude that the cholinergic nervous system plays a modulating role in bronchomotor tone and responses to irritants, but that parasympathetic reflexes are not invariably a major component of human bronchial responses to inhaled allergen.
对豚草敏感的人体受试者，在吸入阿托品预处理前后，吸入浓度逐渐增加的豚草花粉提取物气雾剂。使气道传导率降低35%所需的抗原累积剂量称为PD35。1.2毫克或5毫克的阿托品在抗原激发前可增加气道传导率，但对豚草提取物的PD35没有显著影响，尽管这些剂量的阿托品可抑制气道对吸入氯化乙酰甲胆碱和柠檬酸的反应。我们得出结论，胆碱能神经系统在支气管运动张力和对刺激物的反应中起调节作用，但副交感神经反射并非总是人类支气管对吸入变应原反应的主要组成部分。
