Collins J G, Kendig J J, Mason P
Dept of Anesthesiology, Yale University School of Medicine, New Haven, CT 06514, USA.
Trends Neurosci. 1995 Dec;18(12):549-53. doi: 10.1016/0166-2236(95)98377-b.
The behavioral state known as general anesthesia is the result of actions of general anesthetic agents at multiple sites within the neuraxis. The most common end point used to measure the presence of anesthesia is absence of movement following the presentation of a noxious stimulus. The actions of general anesthetics within the spinal cord have been shown to contribute significantly to the suppression of pain-evoked movements, an important component of clinical anesthesia. Studies in the spinal cord are likely to increase our understanding of the pharmacology by which general anesthetics alter the transmission of somatomotor information. It now appears that the pharmacology responsible for the production of anesthesia is agent- and site-selective, and not the result of a unitary mechanism of action.
被称为全身麻醉的行为状态是全身麻醉药作用于神经轴内多个部位的结果。用于衡量麻醉是否存在的最常见终点是在给予有害刺激后无运动反应。全身麻醉药在脊髓内的作用已被证明对抑制疼痛诱发的运动有显著贡献，这是临床麻醉的一个重要组成部分。对脊髓的研究可能会增进我们对全身麻醉药改变躯体运动信息传递的药理学的理解。现在看来，产生麻醉作用的药理学是具有药物和部位选择性的，而不是单一作用机制的结果。
