Rubin P J, Vorstrup E S, Hemmingsen R P, Andersen H S, Bendsen B B, Strømsø N J, Larsen J K, Bolwig T G
Psykiatrisk afdeling E, Bispebjerg Hospital, København.
Ugeskr Laeger. 1996 Feb 12;158(7):905-10.
Forty-five patients with schizophrenia or schizophreniform disorder admitted to hospital for the first time had a neurological examination, including integrative sensory and complex motor acts, by a trained neurologist. The patients were studied by CT and regional cerebral blood flow as well. A control group of 24 healthy volunteers was included. The patients had significantly more neurological abnormalities (NA) than the healthy volunteers. Medication did not explain the discrepancy. The NA were associated with sulcal enlargement and smaller brains as visualized by CT but not with ventricular enlargement. There was no association between the regional flow values and NA.
45例首次入院的精神分裂症或分裂样精神障碍患者接受了一位经过培训的神经科医生的神经系统检查,包括综合感觉和复杂运动行为检查。这些患者还接受了CT和局部脑血流检查。研究纳入了24名健康志愿者作为对照组。与健康志愿者相比,患者的神经学异常(NA)明显更多。药物治疗无法解释这种差异。CT显示,NA与脑沟增宽和脑体积较小有关,但与脑室扩大无关。局部血流值与NA之间没有关联。