Skjöldebrand-Sparre L, Fridell E, Nyman M, Wahren B
Division of Obstetrics and Gynaecology, Karolinska Institute, Danderyd Hospital, Danderyd, Sweden.
Acta Obstet Gynecol Scand. 1996 Apr;75(4):336-9. doi: 10.3109/00016349609033326.
Parvovirus infection during pregnancy has been reported to be associated with spontaneous abortion and fetal loss.
To show the incidence of antibodies against Parvovirus B19 early in pregnancy and sero-reactivities during and after pregnancy.
In a prospective study during a non-epidemic period, 457 women admitted to an antenatal care center were included. Serum samples were collected at 7-13, 21, and 33 weeks of gestation, and 7-9 weeks after delivery.
Samples were evaluated for parvovirus specific IgG and IgM against two different parvovirus antigens.
Parvovirus specific antibodies were present in 81% of the women in the first sample. Six women (six of 88 susceptible, 6.8%) seroconverted and 28 women (28/369, 7.6%) boosted their antibody response during or after pregnancy. All gave birth to healthy infants. One woman free of symptoms experienced an intrauterine fetal death at 37 weeks of gestation. She had no rise in B19 antibodies during pregnancy, but parvovirus DNA was found in maternal serum samples and in the placenta.
据报道，孕期细小病毒感染与自然流产和胎儿丢失有关。
展示妊娠早期抗细小病毒B19抗体的发生率以及孕期和产后的血清反应性。
在非流行期进行的一项前瞻性研究中，纳入了457名入住产前护理中心的女性。在妊娠7 - 13周、21周、33周以及产后7 - 9周采集血清样本。
针对两种不同的细小病毒抗原评估样本中的细小病毒特异性IgG和IgM。
在首次样本中，81%的女性存在细小病毒特异性抗体。6名女性（88名易感者中的6名，6.8%）发生血清转化，28名女性（28/369，7.6%）在孕期或产后抗体反应增强。所有女性均分娩出健康婴儿。一名无症状女性在妊娠37周时发生宫内胎儿死亡。她在孕期B19抗体未升高，但在母血清样本和胎盘中发现了细小病毒DNA。
