Strandell A, Thorburn J
Department of Obstetrics and Gynecology, The Sahlgrenska University Hospital, Göteborg, Sweden.
Acta Obstet Gynecol Scand. 1996 Apr;75(4):394-9. doi: 10.3109/00016349609033338.
To estimate the risk of subsequent ectopic pregnancy (EP) after tubal surgery, given that the woman becomes pregnant, by means of a logistic model, a retrospective study was initiated.
During the period 1986-1990, 221 women with tubal infertility underwent microsurgery. Subsequent fertility was evaluated in 1991. Ninety women conceived, of whom 84 were included in the study (30 with EP and 54 with intra-uterine pregnancy as the only outcome). Clinical background factors of importance, surgical procedures used, scoring systems for tubal lesions, adnexal adhesions and risk of EP were analysed for possible correlation to subsequent EP. These factors were further used in a logistic model to estimate the risk of subsequent EP as only outcome.
The risk of EP after microsurgery is minimum 15% without any risk factors. Previous EP and endometriosis could be identified as factors with prognostic power in the logistic model. One previous EP implies a 60% risk, whereas two previous EPs and endometriosis increase the risk to 95%.
Patients with previous EP should generally not be considered for microsurgery owing to the high risk of recurrence and to the reduced chance of intra-uterine pregnancy.
为了通过逻辑模型估计输卵管手术后发生异位妊娠(EP)的风险(假设女性怀孕),开展了一项回顾性研究。
1986年至1990年期间,221名输卵管性不孕女性接受了显微手术。1991年对后续生育情况进行了评估。90名女性怀孕,其中84名被纳入研究(30例为异位妊娠,54例以宫内妊娠为唯一结局)。分析了重要的临床背景因素、所采用的手术程序、输卵管病变的评分系统、附件粘连以及异位妊娠风险,以确定其与后续异位妊娠的可能相关性。这些因素进一步用于逻辑模型中,以估计仅作为结局的后续异位妊娠风险。
在没有任何风险因素的情况下,显微手术后异位妊娠的风险至少为15%。在逻辑模型中,既往异位妊娠和子宫内膜异位症可被确定为具有预后价值的因素。既往有一次异位妊娠意味着风险为60%,而既往有两次异位妊娠和子宫内膜异位症则将风险增加至95%。
由于复发风险高且宫内妊娠机会降低,既往有异位妊娠的患者一般不应考虑接受显微手术。