Lin H C, Zhao X T, Chung B, GU Y G, Elashoff J D
Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles 90048-1869, USA.
Am J Physiol. 1996 Mar;270(3 Pt 1):G470-5. doi: 10.1152/ajpgi.1996.270.3.G470.
Little is known about the response of the frequency of gastric pacesetter potential (PP) to luminal distension. When volume distension occurs as a result of a meal, gastric emptying may play an important role, since the site of distension shifts as the meal is displaced from the stomach to the small bowel. In this study, using does equipped with duodenal fistulas and serosal electrodes on the antrum, we compared the frequency of gastric PP during the course of gastric emptying while isolating the volume distension to either the stomach or the small bowel. We found that 1) the frequency of gastric PP decreased linearly with greater initial meal volume when volume distension was isolated to either the stomach -P<0.05, analysis of variance (ANOVA)- or small bowel (P<0.01, ANOVA), and 2) the frequency of gastric PP decreased linearly with increased volume remaining in the stomach or increased volume entering the small intestine. We conclude that the frequency of gastric PP depends on the volume and site of distension.
关于胃起搏电位（PP）频率对管腔扩张的反应，目前所知甚少。当进食导致容量扩张时，胃排空可能起重要作用，因为随着食物从胃排至小肠，扩张部位会发生移动。在本研究中，我们使用配备十二指肠瘘管和胃窦浆膜电极的狗，在胃排空过程中比较胃PP的频率，同时将容量扩张隔离于胃或小肠。我们发现：1）当容量扩张隔离于胃（方差分析，P<0.05）或小肠（方差分析，P<0.01）时，胃PP频率随初始食物量增加呈线性下降；2）胃PP频率随胃内剩余量增加或进入小肠的量增加呈线性下降。我们得出结论，胃PP频率取决于扩张的容量和部位。
