Coupland S E, Sidiki S, Clark B J, McClaren K, Kyle P, Lee W R
Department of Pathology, Western Infirmary, Southern General Hospital, Glasgow.
Arch Ophthalmol. 1996 Jun;114(6):751-6. doi: 10.1001/archopht.1996.01100130743022.
Metastatic uveal melanoma to the contralateral orbit is extremely rare, with only eight cases in the literature having been reported. We reviewed the clinical presentation, the histologic findings of the primary and secondary tumors, and the clinical outcome of these cases and studied an additional case of metastatic choroidal melanoma to the contralateral orbit that occurred 40 years after enucleation for the primary tumor. The long interval between recognition of the primary tumor and the appearance of clinically manifest metastatic disease in the contralateral orbit is the longest reported in the literature to date. The histologic features of the tumor cells of the enucleation specimen and those of the orbital metastasis were similar, consisting of spindle-cell type with minimal atypia. Combined use of immuno-phenotyping and electron microscopy substantiated the diagnosis of melanoma.
葡萄膜黑色素瘤转移至对侧眼眶极为罕见，文献中仅报道过8例。我们回顾了这些病例的临床表现、原发和继发肿瘤的组织学检查结果以及临床转归，并研究了另外1例在原发肿瘤眼球摘除术后40年发生对侧眼眶脉络膜黑色素瘤转移的病例。从发现原发肿瘤到对侧眼眶出现明显转移疾病的时间间隔是迄今为止文献报道中最长的。眼球摘除标本和眼眶转移灶肿瘤细胞的组织学特征相似，均为梭形细胞型，异型性极小。免疫表型分析和电子显微镜检查相结合证实了黑色素瘤的诊断。
