Suwalsky M, Villena F, Aguilar F, Sotomayor C P
Faculty of Chemical Sciences, University of Concepción, Chile.
Z Naturforsch C J Biosci. 1996 Mar-Apr;51(3-4):243-8. doi: 10.1515/znc-1996-3-416.
Penicillin G (PEN) is a widely used antibiotic whose mechanism of action is related to the interference with the synthesis of bacteria cell wall. In order to evaluate its perturbing effect upon human cell membranes PEN was made to interact with human erythrocytes, isolated resealed human erythrocyte membranes and molecular models. The latter were multibilayers of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylethanolamine (DMPE) as well as DMPC large unilamellar vesicles. These studies were performed by scanning electron microscopy, fluorescence spectroscopy and X-ray diffraction methods. The observed results coincide in that PEN did not exert any significant effect upon the structures of the red cell membrane neither on its molecular models. This is in agreement with its reported lack of major toxicity and hematological reactions.
青霉素G（PEN）是一种广泛使用的抗生素，其作用机制与干扰细菌细胞壁的合成有关。为了评估其对人细胞膜的干扰作用，使青霉素G与人红细胞、分离再封闭的人红细胞膜和分子模型相互作用。后者是磷脂二肉豆蔻酰磷脂酰胆碱（DMPC）和二肉豆蔻酰磷脂酰乙醇胺（DMPE）的多层膜以及DMPC大单层囊泡。这些研究通过扫描电子显微镜、荧光光谱法和X射线衍射法进行。观察结果一致表明，青霉素G对红细胞膜结构及其分子模型均未产生任何显著影响。这与其报道的缺乏主要毒性和血液学反应相一致。
