Puri S K, Dutta G P, Levy H B, Maheshwari R K
Central Drug Research Institute, Lucknow, India.
J Interferon Cytokine Res. 1996 Jan;16(1):49-52. doi: 10.1089/jir.1996.16.49.
Prophylatic treatment with a single dose of 1.0 or 2.0 mg/kg (body weight) of polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose (Poly ICLC), a potent interferon (IFN) inducer and immune enhancer, 18 h before intravenous inoculation of sporozoites (1.04 x 10(5)-0.70 x 10(6) sporozoites) of Plasmodium cynomolgi B in the rhesus monkey, completely abolished the infectivity of sporozoites. The inhibitory effect of Poly ICLC is dose dependent in monkeys infected with P. cynomolgi B sporozoites. Treatment with lower doses of Poly ICLC (0.5 mg/kg) provided significant protection, but the lowest dose of Poly ICLC used (0.1 mg/kg) failed to provide any protection. Prophylactic treatment with Poly ICLC, however, had no protective effect against trophozoite-induced infection.
在恒河猴静脉接种食蟹猴疟原虫B子孢子（1.04×10⁵ - 0.70×10⁶个）前18小时，用单剂量1.0或2.0毫克/千克（体重）的聚肌苷酸-聚胞苷酸（用聚赖氨酸和羧甲基纤维素稳定，即Poly ICLC，一种有效的干扰素诱导剂和免疫增强剂）进行预防性治疗，可完全消除子孢子的感染性。Poly ICLC对感染食蟹猴疟原虫B子孢子的猴子的抑制作用呈剂量依赖性。用较低剂量的Poly ICLC（0.5毫克/千克）治疗可提供显著保护，但所用的最低剂量Poly ICLC（0.1毫克/千克）未能提供任何保护。然而，用Poly ICLC进行预防性治疗对滋养体诱导的感染没有保护作用。
