无色素性恶性雀斑样痣黑素瘤：诊断难题——4例新病例报告
Amelanotic lentigo maligna melanoma: a diagnostic conundrum-- presentation of four new cases.
作者信息
Rahbari H, Nabai H, Mehregan A H, Mehregan D A, Mehregan D R, Lipinski J
机构信息
Department of Dermatology, Wayne State University School of Medicine, Detroit, Michigan, USA.
出版信息
Cancer. 1996 May 15;77(10):2052-7. doi: 10.1002/(SICI)1097-0142(19960515)77:10<2052::AID-CNCR13>3.0.CO;2-U.
BACKGROUND
The clinical appearance of amelanotic lentigo maligna melanoma (ALMM) is quite confusing and usually is not diagnosed prior to histopathologic examination.
METHODS
We have studied four new patients with ALMM whose correct diagnosis was not obtained from any one clinical finding. We arrived at the final diagnosis in an unexpected way, having had biopsied the lesions for diagnoses other than malignant melanoma.
RESULTS
ALMM presents as a nonspecific skin lesion with no single indicative characteristic. A search of the literature confirmed our difficulty in making the diagnosis.
CONCLUSIONS
To diagnose ALMM, one has to be cognizant of this condition and has to consider a constellation of findings that are unusual with melanocytic lesions. Questionable lesions must be biopsied for definitive histopathologic diagnosis.
背景
无色素性恶性雀斑样痣黑色素瘤（ALMM）的临床表现相当令人困惑，通常在组织病理学检查之前无法确诊。
方法
我们研究了4例新的ALMM患者，任何一项临床检查结果均未得出正确诊断。我们通过对病变进行活检以进行除恶性黑色素瘤以外的诊断，从而以一种意想不到的方式得出了最终诊断。
结果
ALMM表现为非特异性皮肤病变，没有单一的指示性特征。文献检索证实了我们在诊断方面的困难。
结论
要诊断ALMM，必须认识到这种情况，并且必须考虑一系列黑素细胞病变中不常见的表现。可疑病变必须进行活检以明确组织病理学诊断。
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