Haugen D R, Akslen L A, Varhaug J E, Lillehaug J R
Department of Biochemistry and Molecular Biology, Gade Institute, University of Bergen, Norway.
Cancer Res. 1996 Mar 15;56(6):1184-8.
c-erbB-3 and c-erbB-4 protein expression was analyzed using immunohistochemistry in 138 fresh-frozen thyroid tissue samples from 106 patients, including 56 cases of papillary thyroid carcinoma. Increased expression of c-erbB-3 and c-erbB-4 proteins was observed in papillary carcinomas compared to nonneoplastic thyroid tissue. No amplifications of the c-erbB-3 and c-erbB-4 genes were detected. Coexisting overexpression of epidermal growth factor receptor, c-erbB-2, c-erbB-3, and c-erbB-4 was demonstrated in 36 (64%) of 56 papillary thyroid carcinomas. These findings suggest a common regulatory mechanism for the type I (epidermal growth factor receptor-related) receptors in papillary thyroid carcinomas and provide numerous possibilities for functional receptor interactions.
采用免疫组织化学方法分析了106例患者的138份新鲜冷冻甲状腺组织样本中的c-erbB-3和c-erbB-4蛋白表达情况，其中包括56例甲状腺乳头状癌。与非肿瘤性甲状腺组织相比，在甲状腺乳头状癌中观察到c-erbB-3和c-erbB-4蛋白表达增加。未检测到c-erbB-3和c-erbB-4基因的扩增。在56例甲状腺乳头状癌中，有36例（64%）出现表皮生长因子受体、c-erbB-2、c-erbB-3和c-erbB-4的共过表达。这些发现提示甲状腺乳头状癌中I型（表皮生长因子受体相关）受体存在共同的调控机制，并为功能性受体相互作用提供了多种可能性。
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