Orehek J, Gayrard P, Grimaud C, Charpin J
J Allergy Clin Immunol. 1977 Jun;59(6):414-9. doi: 10.1016/0091-6749(77)90003-3.
The effect of aerosolized prostaglandin F2alpha (PGF2alpha) on specific airway resistance (SRaw) has been measured in patients with common (n = 10) or aspirin-sensitive asthma (n = 5). In all subjects PGF2alpha caused a dose-related increase in SRaw, but considerable individual differences in sensitivity were observed. The patients with aspirin intolerance did not differ from regular asthmatics in terms of their response to PGF2alpha. Two types of reactions to PGF2alpha could be distinguished from their time-course: immediate and short-lasting (3 cases) or delayed and long-lasting (12 cases). Inhalation of a beta-adrenergic drug rapidly and completely reversed the effect of PGF2alpha, suggesting that the increase in SRaw was due to bronchospasm. In 7 subjects the inhalation of an anticholinergic drug (SCH 1000) prior to PGF2alpha inhibited to a large extent the effect of the latter, suggesting that the cholinergic system played an important role in the bronchial response to PGF2alpha. In 9 subjects no correlation was found between the bronchial sensitivity to carbachol and PGF2alpha.
已对普通哮喘患者（n = 10）或阿司匹林敏感型哮喘患者（n = 5）测量了雾化前列腺素F2α（PGF2α）对特异性气道阻力（SRaw）的影响。在所有受试者中，PGF2α均导致SRaw呈剂量相关增加，但观察到敏感性存在相当大的个体差异。阿司匹林不耐受患者对PGF2α的反应与普通哮喘患者并无差异。根据PGF2α反应的时间进程可区分出两种类型：即时且短暂（3例）或延迟且持久（12例）。吸入β-肾上腺素能药物可迅速且完全逆转PGF2α的作用，提示SRaw增加是由于支气管痉挛所致。在7名受试者中，在PGF2α之前吸入抗胆碱能药物（SCH 1000）在很大程度上抑制了后者的作用，提示胆碱能系统在支气管对PGF2α的反应中起重要作用。在9名受试者中，未发现支气管对卡巴胆碱和PGF2α的敏感性之间存在相关性。
