Hata T, Ryukoh K, Fujiwaki R, Hata K, Kitao M, Masumura S
Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan.
Am J Perinatol. 1996 Jan;13(1):11-3. doi: 10.1055/s-2007-994194.
To search for possible effect of dehydroepiandrosterone sulfate (DHAS) on maternal cardiac function in term pregnancy, impedance cardiographic assessments were made on 15 normal full-term pregnant women before and 5, 10, 15, 20, 25, and 30 minutes after the administration of a 200 mg intravenous dose of DHAS in 20 mL of 5% dextrose. The cardiac output, stroke volume, heart rate, and mean arterial pressure were recorded. Maternal cardiac output increased from baseline by 20% (p < 0.05) after 15 minutes and the mean increase in stroke volume was 25% (p < 0.05) after 15 minutes. No change was found in heart rate or mean arterial blood pressure. DHAS induces a significant increase in both maternal stroke volume and cardiac output without change in heart rate or mean arterial pressure, which suggests a possible increase in cardiac contractility in term pregnancy.
为探究硫酸脱氢表雄酮（DHAS）对足月妊娠产妇心功能的可能影响，对15名正常足月孕妇在静脉注射200mg DHAS（溶于20mL 5%葡萄糖溶液）前以及注射后5、10、15、20、25和30分钟进行了阻抗心动图评估。记录心输出量、每搏输出量、心率和平均动脉压。15分钟后产妇心输出量较基线增加20%（p<0.05），15分钟后每搏输出量平均增加25%（p<0.05）。心率和平均动脉血压未发现变化。DHAS可使产妇每搏输出量和心输出量显著增加，而心率和平均动脉压无变化，这表明足月妊娠时心脏收缩力可能增加。
