Adragão P, Parreira L, Morgado F, Almeida M, Mesquita A, Machado F P, Martins D, Bonhorst D, Seabra-Gomes R
Departamento de Arritmologia, Hospital de Santa Cruz.
Rev Port Cardiol. 1996 Feb;15(2):119-28, 100.
The aim of this study was to evaluate our results of radiofrequency catheter ablation (RFCA) of ventricular tachycardia.
We treated with RFCA nine patients, six male and three female, mean age 36 +/- 12 years with ventricular tachycardia (VT), who fulfilled the following criteria; 1) recurrent VT; 2) resistant fo medical therapy despite the use of more than one antiarrhythmic drug; 3) inducible by programmed ventricular stimulation; 4) hemodynamically well tolerated. The VT etiology was coronary artery disease (CAD) in three patients, dilated cardiomyopathy in one, right ventricular dysplasia in one and it was idiopathic in four (being fascicular in three and catecholaminergic right ventricular outflow tract VT in one).
The RFCA was performed under antiarrhythmic medication. The adequate ablation site was obtained by mapping of the VT, looking for the earliest ventricular activation, identification of isolated mid-diastolic potentials during sinus rhythm or presystolic during VT, good pace mapping (at least 10 of the 12 standard ECG leads), and high frequency short duration spikes, the so called P potentials in fascicular VT. Primary success achieved when occurred termination of VT during application of RF energy and/or VT was no longer inducible by programmed stimulation with the same stimulation protocol.
Global primary success rate was 89%, being 100% in idiopathic VT, and 80% in VT associated with structural heart disease. In a follow-up period of 12 +/- 14 months all patients were alive, 75% free of VT in the idiopathic VT group; and 50% in patients with structural heart disease. One of these patients underwent cardioverter defibrillator implantation to treat a fast VT with a new morphology not treated by ablation, and the other two had VT modification with a significant reduction in the number of episodes.
Radiofrequency catheter ablation of VT has shown a good success rate, and it is a valuable alternative in patients with hemodynamically tolerable VT, refractory to drug treatment, highly symptomatic and without surgical indication. In cases of idiopathic VT we had a high rate success and we think that RFCA will probably become the primary indication in symptomatic patients.
本研究旨在评估我们对室性心动过速进行射频导管消融(RFCA)的结果。
我们对9例室性心动过速(VT)患者进行了RFCA治疗,其中男性6例,女性3例,平均年龄36±12岁,这些患者符合以下标准:1)复发性VT;2)尽管使用了一种以上抗心律失常药物,但对药物治疗耐药;3)可通过程序性心室刺激诱发;4)血流动力学耐受性良好。VT的病因在3例患者中为冠状动脉疾病(CAD),1例为扩张型心肌病,1例为右心室发育不良,4例为特发性(3例为束支性,1例为儿茶酚胺能性右心室流出道VT)。
RFCA在抗心律失常药物治疗下进行。通过对VT进行标测来确定合适的消融部位,寻找最早的心室激动,在窦性心律期间识别孤立的舒张中期电位或在VT期间识别收缩前期电位,良好的起搏标测(12个标准心电图导联中至少10个),以及高频短时限尖峰,即束支性VT中所谓的P电位。当在施加RF能量期间VT终止和/或用相同刺激方案进行程序性刺激时VT不再可诱发时,即为初步成功。
总体初步成功率为89%,特发性VT为100%,与结构性心脏病相关的VT为80%。在12±14个月的随访期内,所有患者均存活,特发性VT组中75%无VT发作;结构性心脏病患者中为50%。其中1例患者接受了心脏复律除颤器植入术,以治疗一种消融未治疗的新形态快速VT,另外2例患者进行了VT改良,发作次数显著减少。
VT的射频导管消融显示出良好的成功率,对于血流动力学耐受性良好、药物治疗无效、症状严重且无手术指征的VT患者,它是一种有价值的替代方法。对于特发性VT病例,我们有较高的成功率,并且我们认为RFCA可能会成为有症状患者的主要治疗指征。