一项关于结直肠癌危险因素及p53基因表达的初步研究。
A pilot study on risk factors and p53 gene expression in colorectal cancer.
作者信息
Fredrikson M, Axelson O, Sun X F, Arbman G, Nilsson E, Nordenskjöld B, Sjödahl R, Söderkvist P
机构信息
Department of Occupational and Environmental Medicine, University Hospital, Linköping, Sweden.
出版信息
Br J Cancer. 1996 Jun;73(11):1428-30. doi: 10.1038/bjc.1996.271.
Of 311 colorectal cancers diagnosed in 1984-86 in the county of Ostergotland, Sweden, 179 were included in a case-control study, and, of these, 70 were investigated using immunohistochemical staining for p53 gene mutations. Alcohol use as well as medication with hydralazine-containing antihypertensive drugs, but not heredity were associated with p53 staining. The study is offered to illustrate the possible value of investigating molecularly defined tumour subtypes in relation to specific risk factors.
在瑞典东约特兰省1984 - 1986年诊断出的311例结肠直肠癌中，179例被纳入一项病例对照研究，其中70例使用p53基因突变的免疫组织化学染色进行调查。饮酒以及使用含肼的抗高血压药物与p53染色有关，但遗传因素无关。该研究旨在说明针对特定风险因素研究分子定义的肿瘤亚型的潜在价值。
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