• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
A pilot study on risk factors and p53 gene expression in colorectal cancer.一项关于结直肠癌危险因素及p53基因表达的初步研究。
Br J Cancer. 1996 Jun;73(11):1428-30. doi: 10.1038/bjc.1996.271.
2
Tobacco, alcohol, and p53 overexpression in early colorectal neoplasia.早期结直肠肿瘤中的烟草、酒精与p53过表达
BMC Cancer. 2003 Nov 6;3:29. doi: 10.1186/1471-2407-3-29.
3
Comparison of p53 gene mutation and protein overexpression in colorectal carcinomas.结直肠癌中p53基因突变与蛋白过表达的比较
Br J Cancer. 1994 Oct;70(4):585-90. doi: 10.1038/bjc.1994.355.
4
Familial and nutritional risk factors for p53 overexpression in colorectal cancer.结直肠癌中p53过表达的家族性和营养风险因素。
Cancer Epidemiol Biomarkers Prev. 1996 Apr;5(4):285-91.
5
[p53 mutations and protein overexpression in primary colorectal cancer and its liver metastasis].原发性结直肠癌及其肝转移中的p53突变与蛋白过表达
Zhonghua Zhong Liu Za Zhi. 1999 Mar;21(2):114-8.
6
Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis.突变型p53蛋白和CD44变异蛋白在结直肠癌发生中的表达
Gut. 1995 Jan;36(1):76-80. doi: 10.1136/gut.36.1.76.
7
Humoral response to p53 is associated with conserved domains II and IV mutations in human colorectal cancer: a case-control study in Taiwan.对p53的体液反应与人类结直肠癌中保守结构域II和IV突变相关：台湾的一项病例对照研究
Oncol Rep. 2004 Nov;12(5):1045-51.
8
The prognostic value of the immunohistochemical aspects of tumor suppressor genes p53, bcl-2, PTEN and nuclear proliferative antigen Ki-67 in resected colorectal carcinoma.肿瘤抑制基因p53、bcl-2、PTEN及核增殖抗原Ki-67免疫组化指标在根治性切除结直肠癌中的预后价值
Rom J Morphol Embryol. 2012;53(3):549-56.
9
Family history of cancer, body weight, and p53 nuclear overexpression in Duke's C colorectal cancer.杜克C期结直肠癌的癌症家族史、体重与p53核过表达
Br J Cancer. 1995 Apr;71(4):888-93. doi: 10.1038/bjc.1995.171.
10
p53 nuclear overexpression: an independent predictor of survival in lymph node--positive colorectal cancer patients.p53核过表达：淋巴结阳性结直肠癌患者生存的独立预测指标
J Clin Oncol. 1994 Oct;12(10):2043-50. doi: 10.1200/JCO.1994.12.10.2043.

引用本文的文献

1
Lower Relative Contribution of Positive Family History to Colorectal Cancer Risk with Increasing Age: A Systematic Review and Meta-Analysis of 9.28 Million Individuals.家族史阳性对结直肠癌风险的相对贡献随年龄增长而降低：一项对 928 万人的系统评价和荟萃分析。
Am J Gastroenterol. 2018 Dec;113(12):1819-1827. doi: 10.1038/s41395-018-0075-y. Epub 2018 Jun 5.
2
Tobacco, alcohol, and p53 overexpression in early colorectal neoplasia.早期结直肠肿瘤中的烟草、酒精与p53过表达
BMC Cancer. 2003 Nov 6;3:29. doi: 10.1186/1471-2407-3-29.

本文引用的文献

1
Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis.简单重复序列中普遍存在的体细胞突变揭示了结肠癌发生的一种新机制。
Nature. 1993 Jun 10;363(6429):558-61. doi: 10.1038/363558a0.
2
Clues to the pathogenesis of familial colorectal cancer.家族性结直肠癌的发病机制线索。
Science. 1993 May 7;260(5109):812-6. doi: 10.1126/science.8484121.
3
Do occupational factors influence the risk of colon and rectal cancer in different ways?职业因素是否以不同方式影响结肠癌和直肠癌的风险？
Cancer. 1993 Nov 1;72(9):2543-9. doi: 10.1002/1097-0142(19931101)72:9<2543::aid-cncr2820720906>3.0.co;2-d.
4
Screening patients for heterozygous p53 mutations using a functional assay in yeast.使用酵母中的功能分析筛选杂合p53突变患者。
Nat Genet. 1993 Oct;5(2):124-9. doi: 10.1038/ng1093-124.
5
Colon cancer: a review of the epidemiology.结肠癌：流行病学综述
Epidemiol Rev. 1993;15(2):499-545. doi: 10.1093/oxfordjournals.epirev.a036132.
6
Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.p53肿瘤抑制基因的突变：癌症病因学和分子发病机制的线索
Cancer Res. 1994 Sep 15;54(18):4855-78.
7
Some recent developments in occupational epidemiology.职业流行病学的一些最新进展。
Scand J Work Environ Health. 1994;20 Spec No:9-18.
8
A comment on the reference series with regard to multiple exposure evaluations in a case-referent study.关于病例对照研究中多次暴露评估的参考文献系列的评论。
Scand J Work Environ Health. 1982;8 Suppl 1:15-9.
9
Lifetime occupational exercise and colon cancer.终生职业性运动与结肠癌
Am J Epidemiol. 1985 Sep;122(3):357-65. doi: 10.1093/oxfordjournals.aje.a114116.
10
Body iron stores and the risk of cancer.体内铁储备与癌症风险
N Engl J Med. 1988 Oct 20;319(16):1047-52. doi: 10.1056/NEJM198810203191603.

一项关于结直肠癌危险因素及p53基因表达的初步研究。

A pilot study on risk factors and p53 gene expression in colorectal cancer.

作者信息

Fredrikson M, Axelson O, Sun X F, Arbman G, Nilsson E, Nordenskjöld B, Sjödahl R, Söderkvist P

机构信息

Department of Occupational and Environmental Medicine, University Hospital, Linköping, Sweden.

出版信息

Br J Cancer. 1996 Jun;73(11):1428-30. doi: 10.1038/bjc.1996.271.

DOI:10.1038/bjc.1996.271
PMID:8645592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2074496/
Abstract

Of 311 colorectal cancers diagnosed in 1984-86 in the county of Ostergotland, Sweden, 179 were included in a case-control study, and, of these, 70 were investigated using immunohistochemical staining for p53 gene mutations. Alcohol use as well as medication with hydralazine-containing antihypertensive drugs, but not heredity were associated with p53 staining. The study is offered to illustrate the possible value of investigating molecularly defined tumour subtypes in relation to specific risk factors.

摘要

在瑞典东约特兰省1984 - 1986年诊断出的311例结肠直肠癌中，179例被纳入一项病例对照研究，其中70例使用p53基因突变的免疫组织化学染色进行调查。饮酒以及使用含肼的抗高血压药物与p53染色有关，但遗传因素无关。该研究旨在说明针对特定风险因素研究分子定义的肿瘤亚型的潜在价值。