Sullivan E V, Shear P K, Lim K O, Zipursky R B, Pfefferbaum A
Stanford University School of Medicine, Palo Alto, CA, USA.
Biol Psychiatry. 1996 Feb 15;39(4):234-40. doi: 10.1016/0006-3223(95)00135-2.
This study examined whether the neuropsychological deficits observed in patients with schizophrenia were related to cortical gray matter volume deficits in these patients. All subjects were men and included 34 patients with DSM-III-R Schizophrenia and 47 age-matched healthy controls. Subjects received a battery of 21 tests, assessing four different functional domains: executive functions, short-term memory and production, declarative memory, and motor ability. MRI volumes were corrected for normal variation in head size and age, and neuropsychological test scores were corrected for normal variation in age. The schizophrenic group had significantly smaller cortical gray matter volumes (p < .05) and lower test scores in all functional domain than the control group (p = .0001). Within the schizophrenic group, lower scores in each domain were significantly correlated with smaller total cortical gray matter volumes; however, no predictable relationships were observed between neuropsychological test performance and the volumes of specific cortical regions.
本研究探讨了精神分裂症患者中观察到的神经心理学缺陷是否与这些患者的皮质灰质体积缺陷相关。所有受试者均为男性，包括34例符合DSM-III-R精神分裂症诊断标准的患者和47名年龄匹配的健康对照者。受试者接受了一组共21项测试，评估四个不同的功能领域：执行功能、短期记忆与生成、陈述性记忆和运动能力。对MRI体积进行了头部大小和年龄正常变异的校正，对神经心理学测试分数进行了年龄正常变异的校正。精神分裂症组的皮质灰质体积显著更小（p < 0.05），并且在所有功能领域的测试分数均低于对照组（p = 0.0001）。在精神分裂症组内，每个领域的较低分数与总的皮质灰质体积较小显著相关；然而，未观察到神经心理学测试表现与特定皮质区域体积之间存在可预测的关系。
