Myles-Worsley M, Coon H, Byerley W, Waldo M, Young D, Freedman R
Department of Psychiatry, University of Utah School of Medicine, Salt Lake City 84132, USA.
Biol Psychiatry. 1996 Feb 15;39(4):289-95. doi: 10.1016/0006-3223(95)00134-4.
Evoked potentials to pairs of click stimuli were recorded from 127 subjects ranging in age from 10 to 39 years to examine the developmental course of auditory sensory gating. The ratio of the amplitude of the second response to that of the first provides a quantitative measure of auditory sensory gating. Contrary to earlier results, the distribution of P50 ratios was unchanged between children and younger adolescents (10-14 years), older adolescents (15-19 years), and adults (20-29 and 30-39 years). Included in the sample were 39 adolescent twins, allowing assessment for possible genetic effects underlying the P50 sensory gating phenotype, by comparison of the similarity of the measure in monozygotic and same-sex dizygotic twin pairs. The monozygotic twins had significantly higher similarity for the P50 ratio within each twin pair than the dizygotic twins. These results are consistent with the presence of genetic influences on the P50 sensory gating phenotype.
对127名年龄在10至39岁之间的受试者记录了对成对点击刺激的诱发电位，以研究听觉感觉门控的发育过程。第二个反应的幅度与第一个反应幅度的比值提供了听觉感觉门控的定量测量。与早期结果相反，儿童、青少年早期（10 - 14岁）、青少年晚期（15 - 19岁）和成年人（20 - 29岁和30 - 39岁）之间P50比值的分布没有变化。样本中有39对青少年双胞胎，通过比较同卵双胞胎和同性异卵双胞胎对中测量值的相似性，可以评估P50感觉门控表型潜在的遗传效应。同卵双胞胎对中P50比值的相似性明显高于异卵双胞胎。这些结果与P50感觉门控表型存在遗传影响一致。
