Young D A, Waldo M, Rutledge J H, Freedman R
Department of Preventive Medicine and Biometrics, University of Colorado School of Medicine, Denver, USA.
Neuropsychobiology. 1996;33(3):113-7. doi: 10.1159/000119260.
Most normal subjects suppress the P50 evoked response to repeated auditory stimulus when paired stimuli are presented, 500 ms apart. The ratio of the amplitude of the response to the second stimulus to that of the first forms a quantitative measure of the activity of a central inhibitory sensory gating mechanism. The variance of this measure in a group of monozygotic and dizygotic twin pairs was determined. The calculation of heritability (h2) indicates that a significant portion of the variance (0.44 or greater) is due to heritable factors. This study supports the use of the inhibitory gating of the P50 response as a phenotype for genetic studies of schizophrenia in which a P50 gating abnormality has been identified.
当呈现间隔500毫秒的配对刺激时，大多数正常受试者会抑制对重复听觉刺激诱发的P50反应。对第二个刺激的反应幅度与第一个刺激的反应幅度之比，形成了一种对中枢抑制性感觉门控机制活动的定量测量。测定了一组同卵和异卵双胞胎对该测量值的方差。遗传度（h2）的计算表明，很大一部分方差（0.44或更大）归因于遗传因素。这项研究支持将P50反应的抑制性门控用作精神分裂症遗传研究的一种表型，在精神分裂症中已发现P50门控异常。
