Rex J H, Bennett J E, Sugar A M, Pappas P G, Serody J, Edwards J E, Washburn R G
University of Texas Medical School at Houston 77030, USA.
Clin Infect Dis. 1995 Oct;21(4):994-6. doi: 10.1093/clinids/21.4.994.
During a comparative trial of amphotericin B vs. fluconazole for treatment of candidemia in nonneutropenic patients, data on the management of intravascular catheters were collected. Complete records were available for 91% of the 206 study patients. For the subset of patients with a catheter in place at the time of their first positive blood culture, removal and replacement of all intravascular catheters without exchange over a guidewire from a preexisting line on or before the first day the study drug was administered were associated with a reduction in the subsequent mean duration (+/- SE) of candidemia, from 5.6 +/ -0.8 days to 2.6 +/- 0.5 days (P < .001).
