Caron A, Menu P, Faivre B, Labrude P, Vigneron C
Laboratoire d'Hématologie et de Physiologie, Faculté des Sciences Pharmaceutiques et Biologiques, Université Henri-Poincaré-Nancy 1, France.
Transfus Clin Biol. 1995;2(6):453-62. doi: 10.1016/s1246-7820(05)80071-0.
The effects of Dextran-Benzene-Tetracarboxylate-Hemoglobin (Dex-BTC-Hb), a chemically-modified hemoglobin-based oxygen carrier, on the vascular tone were compared to those of standard solutions, i.e. the animal's own blood and a 50 milligrams albumin solution, by measuring the carotid blood flow velocity, the mean arterial pressure, the heart rate and respiratory frequency, in anesthetized Hartley guinea pigs after a hemorragic shock. Stroma-free hemoglobin induced 40% hypertension and a 110% rise in blood flow velocity immediately after injection. The velocity was still increased 38%, 3 hours after injection. The calculations of the vascular resistances showed an increase in carotid vascular tone. Dex-BTC-Hb brought about 35% hypertension for two hours with no significant modifications of the vascular tone. These effects are similar to those of the albumin solution. These results indicate that, unlike stroma-free hemoglobin, Dex-BTC-Hb does not significantly affect the vascular tone, probably because of its slight interaction with the factors that regulate vascular tone.
通过测量失血性休克后麻醉的哈特利豚鼠的颈动脉血流速度、平均动脉压、心率和呼吸频率，比较了化学修饰的基于血红蛋白的氧载体葡聚糖-苯四羧酸-血红蛋白（Dex-BTC-Hb）与标准溶液（即动物自身血液和50毫克白蛋白溶液）对血管张力的影响。无基质血红蛋白注射后立即引起40%的高血压和110%的血流速度升高。注射3小时后，血流速度仍增加38%。血管阻力的计算显示颈动脉血管张力增加。Dex-BTC-Hb在两小时内引起35%的高血压，而血管张力无明显改变。这些作用与白蛋白溶液的作用相似。这些结果表明，与无基质血红蛋白不同，Dex-BTC-Hb不会显著影响血管张力，这可能是因为它与调节血管张力的因子相互作用较弱。
