Nomura A, Stemmermann G N, Chyou P H, Tabor E
Japan-Hawaii Cancer Study, Kuakini Medical Center, Honolulu, Hawaii 96817, USA.
J Infect Dis. 1996 Jun;173(6):1474-6. doi: 10.1093/infdis/173.6.1474.
A cohort of 5924 Japanese American men was examined between 1967 and 1970 for hepatocellular carcinoma (HCC). By 1992, 24 incident cases of HCC were histologically confirmed in the group. Frozen serum samples from the 24 men with HCC and 72 age-matched controls were tested for hepatitis B surface antigen (HBsAg), antibodies to hepatitis B core antigen, antibodies to HBsAg, and antibodies to hepatitis C virus. HBsAg was detected in 15 (62.5%) of 24 HCC cases compared with 2 (2.8%) of 72 controls (odds ratio, 43.0; 95% confidence interval, 5.7-325.5). None of the cases and only 1 control had antibody to hepatitis C virus. This study demonstrates a strong association between hepatocellular carcinoma and hepatitis B virus infection, but not with hepatitis C virus infection, among men of Japanese ancestry in Hawaii.
1967年至1970年间，对一组5924名日裔美国男性进行了肝细胞癌（HCC）检查。到1992年，该组中有24例新发肝细胞癌病例经组织学确诊。对24名肝细胞癌男性患者和72名年龄匹配的对照者的冷冻血清样本进行了乙肝表面抗原（HBsAg）、乙肝核心抗体、乙肝表面抗体和丙肝病毒抗体检测。24例肝细胞癌病例中有15例（62.5%）检测到HBsAg，而72名对照者中只有2例（2.8%）检测到（优势比为43.0；95%置信区间为5.7 - 325.5）。所有病例中均未检测到丙肝病毒抗体，只有1名对照者检测到丙肝病毒抗体。这项研究表明，在夏威夷的日裔男性中，肝细胞癌与乙肝病毒感染之间存在密切关联，但与丙肝病毒感染无关。
