Chariyalertsak S, Sirisanthana T, Supparatpinyo K, Nelson K E
Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Thailand.
J Infect Dis. 1996 Jun;173(6):1490-3. doi: 10.1093/infdis/173.6.1490.
Disseminated Penicillium marneffei infections are common AIDS-defining opportunistic infections among persons with human immunodeficiency virus (HIV) infection in northern Thailand. Penicilliosis due to P. marneffei is the third most frequent AIDS-defining infection in this population, after tuberculosis and cryptococcosis. Very little is known about the epidemiology and natural reservoir of P. marneffei. The seasonal distribution of two common AIDS-defining fungal infections was compared among patients diagnosed between 1991 and 1994 at Chiang Mai University Hospital. There were 550 cases (492 male, 58 female patients) of P. marneffei and 793 cases (685 male, 108 female patients) of Cryptococcus neoformans infection diagnosed. In each year, P. marneffei but not C. neoformans infections were more frequent in the rainy than the dry season. Seasonal variation of P. marneffei infections in AIDS patients in northern Thailand may provide valuable information in determining the important reservoirs and exposures to this organism that lead to disseminated disease in these patients.
播散性马尔尼菲青霉感染是泰国北部人类免疫缺陷病毒（HIV）感染者中常见的艾滋病界定机会性感染。马尔尼菲青霉所致的青霉病是该人群中第三常见的艾滋病界定感染，仅次于结核病和隐球菌病。人们对马尔尼菲青霉的流行病学和自然宿主知之甚少。对1991年至1994年在清迈大学医院诊断的患者中两种常见的艾滋病界定真菌感染的季节性分布进行了比较。共诊断出550例马尔尼菲青霉感染病例（492例男性，58例女性患者）和793例新型隐球菌感染病例（685例男性，108例女性患者）。每年，马尔尼菲青霉感染在雨季比旱季更常见，而新型隐球菌感染并非如此。泰国北部艾滋病患者中马尔尼菲青霉感染的季节性变化可能为确定导致这些患者发生播散性疾病的该病原体的重要宿主和暴露因素提供有价值的信息。
