Cooper C R, McGinnis M R
Department of Pathology, University of Texas Medical Branch, Galveston 77555-0609, USA.
Arch Pathol Lab Med. 1997 Aug;121(8):798-804.
To summarize current knowledge regarding the opportunistic dimorphic fungal pathogen Penicillium marneffei. Clinical presentation, differential diagnosis, mycology, histopathology, diagnostic serology, in vitro antifungal agent susceptibility testing, and therapy are discussed for human immunodeficiency virus-infected individuals primarily living in Southeast Asia.
Critical evaluation of peer-reviewed publications located through an electronic literature database search, supplemented by unpublished observations, were used to prepare this report.
Studies were selected based on either the fungal name Penicillium marneffei, penicilliosis, penicilliosis marneffei, or a combination of these.
Articles were reviewed with appropriate data being abstracted and then synthesized into the review.
Differential diagnostic criteria for tissue diagnosis and laboratory identification of the fungus are detailed. The usefulness of mycoserology and antifungal therapy are evaluated.
Penicillium marneffei is an emerging pathogen, primarily among patients with acquired immunodeficiency syndrome residing in Southeast Asia. Although infection caused by P marneffei is endemic to this portion of the world, cases are being diagnosed and treated involving individuals who have traveled to this region. Penicilliosis marneffei can clinically resemble tuberculosis, molluscum contagiosum, cryptococcosis, and histoplasmosis. The successful treatment of P marneffei infection is dependent on its rapid and accurate diagnosis.
总结关于机会性双相真菌病原体马尔尼菲青霉的现有知识。主要针对生活在东南亚的人类免疫缺陷病毒感染者，讨论其临床表现、鉴别诊断、真菌学、组织病理学、诊断血清学、体外抗真菌药敏试验及治疗方法。
通过电子文献数据库搜索找到的同行评审出版物的批判性评估，并辅以未发表的观察结果，用于编写本报告。
根据真菌名称马尔尼菲青霉、青霉病、马尔尼菲青霉病或这些名称的组合来选择研究。
对文章进行评审，提取适当的数据，然后综合到综述中。
详细阐述了真菌组织诊断和实验室鉴定的鉴别诊断标准。评估了真菌血清学和抗真菌治疗的实用性。
马尔尼菲青霉是一种新兴病原体，主要见于居住在东南亚的获得性免疫缺陷综合征患者。尽管马尔尼菲青霉引起的感染在世界这一地区为地方病，但现在也有前往该地区的旅行者被诊断和治疗该病例。马尔尼菲青霉病在临床上可能类似于结核病、传染性软疣、隐球菌病和组织胞浆菌病。马尔尼菲青霉感染的成功治疗取决于其快速准确的诊断。
