Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong.
Mycopathologia. 2019 Dec;184(6):721-729. doi: 10.1007/s11046-019-00395-y.
The fungus Talaromyces marneffei was described by Professor Gabriel Segretain in 1959, originally as a member of the genus Penicillium. As early as 60 years ago, its peculiarity in exhibiting temperature-dependent morphological dimorphism, its characteristic ability to secrete diffusing red pigment during the mycelial phase and its pathogenicity have already been recognised. Six decades have passed, and our understanding on this intriguing fungus has improved. Apart from the clinical aspect, we have gained a glimpse on its taxonomy, animal or environmental source(s), mechanism of thermal dimorphism, molecular genetics, virulence as well as pathogenesis. However, we are still on our way to get out of the talaromycosis mist. A lot more collective endeavour on T. marneffei research is needed to solve the jigsaw puzzle.
马尔尼菲青霉由 Gabriel Segretain 教授于 1959 年描述，最初被归为青霉属的一员。早在 60 年前，人们就已经认识到它具有温度依赖性形态二态性的特点、在菌丝期分泌扩散性红色色素的能力以及致病性。60 年过去了，我们对这种奇特真菌的认识也有所提高。除了临床方面，我们还对其分类学、动物或环境来源、热二态性机制、分子遗传学、毒力以及发病机制有了一定的了解。然而，我们仍然需要更多的努力来揭开马尔尼菲青霉病的神秘面纱。为了解决这个难题，需要更多的集体努力来研究马尔尼菲青霉。
