Kawashima M
Jpn J Antibiot. 1980 Mar;33(3):249-52.
Cefazolin (CEZ) concentration in the bone marrow of tibia was examined 1, 2 and 3 hours after intramuscular injection of 1 g. CEZ concentration in the bone marrow of tibia 1 hour after injection was 59.9+/-10.31 microgram/ml. Ratio to serum was 101.7%. CEZ concentration in the bone marrow of tibia 2 hours after injection was 42.5+/-7.77 microgram/ml. Ratio to serum was 102.7%. CEZ concentration in the bone marrow of tibia 3 hours after injection was 33.9+/-7.75 microgram/ml. Ratio to serum was 102.7%. Penetration capacity of CEZ into the bone marrow of tibia was excellent.
