伴有固定真声带的声门癌：新辅助化疗及环状软骨上部分喉切除术联合环状软骨舌骨会厌固定术后的疗效
Glottic carcinoma with a fixed true vocal cord: outcomes after neoadjuvant chemotherapy and supracricoid partial laryngectomy with cricohyoidoepiglottopexy.
作者信息
Laccourreye O, Salzer S J, Brasnu D, Shen W, Laccourreye H, Weinstein G S
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, Hôpital Laënnec, Paris, France.
出版信息
Otolaryngol Head Neck Surg. 1996 Mar;114(3):400-6. doi: 10.1016/S0194-59989670209-7.
Twenty patients with glottic squamous cell carcinoma and a fixed true vocal cord underwent neoadjuvant chemotherapy followed by supracricoid partial laryngectomy with cricohyoidoepiglottopexy. Phonation, respiration, and deglutition were preserved. Local control was better than has been previously reported for either extended vertical partial laryngectomy or radiation therapy. All patients were monitored for at least 3 years or until death. The Kaplan-Meier 3-year survival, local recurrence, nodal recurrence, distant metastasis, and second primary rates were 75%, 10.8%, 5%, 10.8%, and 10.8%, respectively. Overall local control was achieved in all cases, and laryngeal preservation in 90%. Our experience suggested that neoadjuvant chemotherapy with supracricoid partial laryngectomy with cricohyoidoepiglottopexy deserves further consideration in the treatment of glottic tumors with a fixed true vocal cord.
20例声门型鳞状细胞癌且一侧真声带固定的患者接受了新辅助化疗，随后进行了环状软骨上部分喉切除术加环状软骨舌骨会厌固定术。患者的发声、呼吸及吞咽功能均得以保留。局部控制情况优于既往报道的扩大垂直部分喉切除术或放射治疗。所有患者均接受了至少3年的随访或直至死亡。采用Kaplan-Meier法分析得出的3年生存率、局部复发率、区域淋巴结复发率、远处转移率及第二原发癌发生率分别为75%、10.8%、5%、10.8%和10.8%。所有病例均实现了总体局部控制，90%的患者实现了喉功能保留。我们的经验表明，新辅助化疗联合环状软骨上部分喉切除术加环状软骨舌骨会厌固定术在治疗一侧真声带固定的声门型肿瘤方面值得进一步研究。
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