Nestor K E, Saif Y M, Zhu J, Noble D O, Patterson R A
Department of Animal Sciences, Ohio Agricultural Research and Development Center, Ohio State University, Wooster 44691, USA.
Poult Sci. 1996 Jan;75(1):29-33. doi: 10.3382/ps.0750029.
Sublines homozygous for each of four MHC haplotypes were developed from randombred control populations of turkeys and challenged with Pasteurella multocida (capsular serogroup a, somatic serotype 3, 4) at 6 wk of age or Newcastle disease virus (NDV; Texas GB strain) at 4 wk of age. In addition, individuals from a randombred control line (RBC2) and a subline (F) of RBC2 long-term selected for increased 16-wk BW were included in most of the challenge trials. The duration of the challenge trials was 2 wk for both organisms. Mortality following challenge with P. multocida or NDV was higher in the F line than in its randombred control. The MHC genotypes differed in mortality following exposure to both organisms but the rankings of the genotypes were not the same for P. multocida and NDV. The increased susceptibility of the F line to both organisms could not be explained by known changes in the frequency of the MHC haplotypes.
从火鸡的随机交配对照群体中培育出了分别对四种主要组织相容性复合体（MHC）单倍型呈纯合状态的亚系，并在6周龄时用多杀性巴氏杆菌（荚膜血清群a，菌体血清型3、4）进行攻毒，或在4周龄时用新城疫病毒（NDV；德克萨斯GB株）进行攻毒。此外，在大多数攻毒试验中还纳入了来自随机交配对照系（RBC2）以及为提高16周龄体重而长期选育的RBC2亚系（F）的个体。两种病原体的攻毒试验持续时间均为2周。F系在多杀性巴氏杆菌或NDV攻毒后的死亡率高于其随机交配对照系。MHC基因型在接触两种病原体后的死亡率存在差异，但多杀性巴氏杆菌和NDV的基因型排名不同。F系对两种病原体易感性增加无法用MHC单倍型频率的已知变化来解释。
