Yamada-Tanaka M S, Ferreira-da-Cruz M F, Alecrim M G, Mascarenhas L A, Daniel-Ribeiro C T
Department of Immunology, World Health Organization, Instituto Oswaldo Cruz-FIOCRUZ, Rio de Janeiro, Brazil.
Trop Geogr Med. 1995;47(6):282-5.
We compared the tumor necrosis factor (TNF-alpha), interferon gamma (IFN-gamma) and granulocyte-macrophage colony stimulating factor (GM-CSF) serum levels in 87 patients with malaria from the Brazilian Amazon. They included asymptomatic infected individuals and symptomatic patients with mild disease or severe malaria with or without cerebral involvement. As controls we examined individuals living in endemic areas without past history of malaria. The TNF-alpha serum levels were increased in patients with malaria and progressively decreased in those with severe disease 7 days after specific treatment. We found correlation between parasitaemia, TNF-alpha levels and severity of the disease. The correlation between high TNF-alpha levels and severe malaria was independent of cerebral involvement. The increase in both IFN-gamma and GM-CSF levels among malarious patients was not related to the degree of severity or mortality. IFN-gamma concentration, however, was associated with high parasitaemia at admission.
我们比较了来自巴西亚马逊地区的87例疟疾患者的肿瘤坏死因子（TNF-α）、干扰素γ（IFN-γ）和粒细胞巨噬细胞集落刺激因子（GM-CSF）血清水平。这些患者包括无症状感染者以及患有轻度疾病或严重疟疾（伴有或不伴有脑部受累）的有症状患者。作为对照，我们检查了生活在疟疾流行地区且无疟疾既往史的个体。疟疾患者的TNF-α血清水平升高，在接受特异性治疗7天后，重症患者的该水平逐渐下降。我们发现疟原虫血症、TNF-α水平与疾病严重程度之间存在相关性。高TNF-α水平与严重疟疾之间的相关性与脑部受累无关。疟疾患者中IFN-γ和GM-CSF水平的升高与疾病严重程度或死亡率无关。然而，IFN-γ浓度与入院时的高疟原虫血症相关。
