Amato R J, Ellerhorst J, Banks M, Logothetis C J
Department of Genitourinary Oncology, University of Texas, Houston 77030, USA.
Eur J Cancer. 1995 Dec;31A(13-14):2223-8. doi: 10.1016/0959-8049(95)00341-x.
This prospective phase II study assesses the clinical efficacy and complications of a treatment regimen comprising combination chemotherapy with carboplatin and ifosfamide and selective consolidation in advanced seminoma. Of 43 patients who entered the study, between May 1989 and May 1992, 42 were evaluable. 30 achieved a complete remission (71%; 95% confidence interval, 56-84%) after chemotherapy alone. 10 achieved a complete remission (24%; 95% confidence interval, 13-39%) after chemotherapy plus consolidation. 38 of the 42 patients (91%; 95% confidence interval, 83-98%) remained in remission after a median follow-up period of 35 months (20-56 months). No patient experienced nephrotoxic, neurotoxic, or ototoxic effects, or haemorrhagic cystitis. Ten per cent of the patients had leucopenic fever requiring hospitalisation. Twenty-four per cent required platelet transfusions, and 26% required transfusions of packed red blood cells. For patients with seminoma, treatment with carboplatin and ifosfamide and selective consolidation is safe and effective.
这项前瞻性II期研究评估了包含卡铂和异环磷酰胺联合化疗及晚期精原细胞瘤选择性巩固治疗方案的临床疗效和并发症。在1989年5月至1992年5月期间进入该研究的43例患者中，42例可进行评估。仅化疗后，30例达到完全缓解（71%；95%置信区间，56 - 84%）。化疗加巩固治疗后，10例达到完全缓解（24%；95%置信区间，13 - 39%）。42例患者中的38例（91%；95%置信区间，83 - 98%）在中位随访期35个月（20 - 56个月）后仍处于缓解状态。没有患者出现肾毒性、神经毒性或耳毒性作用，也没有出现出血性膀胱炎。10%的患者出现需要住院治疗的白细胞减少性发热。24%的患者需要输注血小板，26%的患者需要输注浓缩红细胞。对于精原细胞瘤患者，卡铂和异环磷酰胺治疗及选择性巩固治疗是安全有效的。
