The Bcl I polymorphism of the human uncoupling protein (ucp) gene is due to a point mutation in the 5'-flanking region.

作者信息

Cassard-Doulcier A M, Bouillaud F, Chagnon M, Gelly C, Dionne F T, Oppert J M, Bouchard C, Chagnon Y, Ricquier D

机构信息

Centre de Recherche sur l'Endocrinologie Moléculaire et le Développement, Centre National de la Recherche Scientifique, Meudon, France.

出版信息

Int J Obes Relat Metab Disord. 1996 Mar;20(3):278-9.

The polymorphic Bcl I site in the human ucp gene associated to percentage fat gain over time in the Québec Family Study cohort (Oppert et al. Int J Obesity 1994; 18: 526-531) has been positioned to the 5'-flanking region. This polymorphism results from a unique A/G mutation. Oligonucleotides used to amplify the polymorphic region, and allowing future studies of any cohort of patients, are described.