• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The Bcl I polymorphism of the human uncoupling protein (ucp) gene is due to a point mutation in the 5'-flanking region.

作者信息

Cassard-Doulcier A M, Bouillaud F, Chagnon M, Gelly C, Dionne F T, Oppert J M, Bouchard C, Chagnon Y, Ricquier D

机构信息

Centre de Recherche sur l'Endocrinologie Moléculaire et le Développement, Centre National de la Recherche Scientifique, Meudon, France.

出版信息

Int J Obes Relat Metab Disord. 1996 Mar;20(3):278-9.

PMID:8653151
Abstract

The polymorphic Bcl I site in the human ucp gene associated to percentage fat gain over time in the Québec Family Study cohort (Oppert et al. Int J Obesity 1994; 18: 526-531) has been positioned to the 5'-flanking region. This polymorphism results from a unique A/G mutation. Oligonucleotides used to amplify the polymorphic region, and allowing future studies of any cohort of patients, are described.

摘要

相似文献

1
The Bcl I polymorphism of the human uncoupling protein (ucp) gene is due to a point mutation in the 5'-flanking region.
Int J Obes Relat Metab Disord. 1996 Mar;20(3):278-9.
2
DNA polymorphism in the uncoupling protein (UCP) gene and human body fat.解偶联蛋白（UCP）基因中的DNA多态性与人体脂肪
Int J Obes Relat Metab Disord. 1994 Aug;18(8):526-31.
3
Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity.来自aP2基因启动子的线粒体解偶联蛋白基因的表达可预防遗传性肥胖。
J Clin Invest. 1995 Dec;96(6):2914-23. doi: 10.1172/JCI118363.
4
Uncoupling protein-1 mRNA expression in obese human subjects: the role of sequence variations at the uncoupling protein-1 gene locus.肥胖人类受试者中解偶联蛋白-1 mRNA的表达：解偶联蛋白-1基因位点序列变异的作用。
J Lipid Res. 1998 Apr;39(4):834-44.
5
DNA polymorphism in the uncoupling protein 1 (UCP1) gene has no effect on obesity related phenotypes in the Swedish Obese Subjects cohorts.解偶联蛋白1（UCP1）基因中的DNA多态性对瑞典肥胖受试者队列中与肥胖相关的表型没有影响。
Int J Obes Relat Metab Disord. 1998 Jun;22(6):500-5. doi: 10.1038/sj.ijo.0800613.
6
Delineation of thyroid hormone-responsive sequences within a critical enhancer in the rat uncoupling protein gene.大鼠解偶联蛋白基因关键增强子内甲状腺激素反应序列的描绘。
Endocrinology. 1995 Mar;136(3):1003-13. doi: 10.1210/endo.136.3.7867554.
7
Frequency and significance of the A-->G (-3826) polymorphism in the promoter of the gene for uncoupling protein-1 with regard to metabolic parameters and adipocyte transcription factor binding in a large population-based Caucasian cohort.在一个基于大量白种人群队列中，解偶联蛋白-1基因启动子中A-->G (-3826)多态性与代谢参数及脂肪细胞转录因子结合的频率和意义。
Eur J Clin Invest. 1999 Sep;29(9):770-9. doi: 10.1046/j.1365-2362.1999.00529.x.
8
Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4.人类解偶联蛋白基因：结构、与大鼠基因的比较以及在4号染色体长臂上的定位
J Cell Biochem. 1990 Jul;43(3):255-64. doi: 10.1002/jcb.240430306.
9
GG-genotype in the promotor region of uncoupling-protein-1 gene is associated with lower level of dehydroepiandrosterone in type 2 diabetes.解偶联蛋白-1基因启动子区域的GG基因型与2型糖尿病患者较低水平的脱氢表雄酮相关。
Exp Clin Endocrinol Diabetes. 2001;109(2):102-6. doi: 10.1055/s-2001-14829.
10
Uncoupling protein-2/uncoupling protein-3 gene polymorphism is not associated with anorexia nervosa.解偶联蛋白2/解偶联蛋白3基因多态性与神经性厌食症无关。
Psychiatr Genet. 2004 Dec;14(4):215-8. doi: 10.1097/00041444-200412000-00009.

引用本文的文献

1
Brown Adipose Tissue-A Translational Perspective.棕色脂肪组织——转化视角。
Endocr Rev. 2023 Mar 4;44(2):143-192. doi: 10.1210/endrev/bnac015.
2
Association of Uncoupling Protein 1 (UCP1) gene polymorphism with obesity: a case-control study.解偶联蛋白1（UCP1）基因多态性与肥胖的关联：一项病例对照研究。
BMC Med Genet. 2018 Nov 20;19(1):203. doi: 10.1186/s12881-018-0715-5.
3
Reduction of HbA1c levels by fucoxanthin-enriched akamoku oil possibly involves the thrifty allele of uncoupling protein 1 (): a randomised controlled trial in normal-weight and obese Japanese adults.
富含岩藻黄质的秋紫苏油降低糖化血红蛋白（HbA1c）水平可能与解偶联蛋白1（UCP1）的节俭基因有关：一项针对正常体重和肥胖日本成年人的随机对照试验
J Nutr Sci. 2017 Feb 14;6:e5. doi: 10.1017/jns.2017.1. eCollection 2017.
4
The polymorphisms of UCP1 genes associated with fat metabolism, obesity and diabetes.与脂肪代谢、肥胖和糖尿病相关的 UCP1 基因多态性。
Mol Biol Rep. 2010 Mar;37(3):1513-22. doi: 10.1007/s11033-009-9550-2. Epub 2009 May 15.
5
Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio.解偶联蛋白1和3基因多态性与腰臀比相关。
J Mol Med (Berl). 2003 May;81(5):327-32. doi: 10.1007/s00109-003-0431-1. Epub 2003 Mar 28.
6
The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP.解偶联蛋白同源物：UCP1、UCP2、UCP3、StUCP和AtUCP。
Biochem J. 2000 Jan 15;345 Pt 2(Pt 2):161-79.