Iatrou C, Afentakis N, Antonopoulou S, Andrikopoulos N, Demopoulos C A, Ziroyannis P
Department of Nephrology, General Hospital of Athens, Greece.
Int J Artif Organs. 1995 Jul;18(7):355-61.
There is evidence that PAF may be produced during hemodialysis (HD) mainly when using cuprophane membrane (CU). It is also known that PAF production is dependent on the amount of extracellular calcium (ECa2+). In the present study, we investigated the production of PAF during HD with CU as well as the role of the Ca2+ in the dialysate with respect to PAF production. Five hemodialyzed patients were studied in two consecutive HD sessions (the first performed using dialysate without Ca2+ and the second with a Ca2+ concentration of 3.25 mEq/L) and at different times during the sessions the circulating PAF levels as well as the leukocyte and platelet counts were measured. The results demonstrated that a) PAF was indeed produced during HD with CU, b) the highest PAF levels in blood were observed between 5 and 15 minutes from the beginning of HD, at which time the lowest circulating leukocyte and platelet count were measured and c) PAF levels in blood were inversely proportional to the Ca2+ concentration in the dialysate (with the exceptional case of the 15 minutes), although we expected the opposite results.
有证据表明，PAF可能主要在使用铜仿膜（CU）进行血液透析（HD）期间产生。还已知PAF的产生取决于细胞外钙（ECa2+）的量。在本研究中，我们调查了使用CU进行HD期间PAF的产生情况，以及透析液中Ca2+在PAF产生方面的作用。对五名接受血液透析的患者进行了连续两次HD治疗（第一次使用不含Ca2+的透析液，第二次使用Ca2+浓度为3.25 mEq/L的透析液），并在治疗期间的不同时间测量了循环PAF水平以及白细胞和血小板计数。结果表明：a）使用CU进行HD期间确实会产生PAF；b）在HD开始后5至15分钟之间观察到血液中PAF水平最高，此时测量到的循环白细胞和血小板计数最低；c）血液中的PAF水平与透析液中的Ca2+浓度成反比（15分钟时的情况除外），尽管我们预期会得到相反的结果。
