Kabasakal C, Mir S, Gousseinov A, Cura A, Betin N, Coker I
Department of Pediatrics, Ege University, Faculty of Medicine, Tepecik Social Security Hospital, Izmir.
Turk J Pediatr. 1998 Jul-Sep;40(3):413-20.
Inflammatory lipid mediators, PAF and leukotrienes (LTs), are thought to have an important role in biocompatibility in hemodialysis. PAF, LTB4 and LTC4 were studied both in controls (n: 12) and in 11 children on regular hemodialysis (150 minutes) with cuprophane dialyzers. Blood samples were collected initially (0'-precapillary), at first minute (1'-postcapillary) and at one hour after the hemodialysis sessions (210'-venous). Presence of LTs and high levels of PAF in 0' samples compared to levels in controls and significant increases in 1' samples suggested the alterations in PAF and LTs likely originated from the peripheral leukocyte activation. In 210' samples, PAF and LTs levels were decreased but still higher than the levels in 0' samples. This study suggested that PAF and LTB4 may be the control elements in biocompatibility in hemodialysis with cuprophane membranes, and demonstrated that the effects of activation last until the following session.
炎症性脂质介质，血小板活化因子（PAF）和白三烯（LTs），被认为在血液透析的生物相容性中起重要作用。对12名健康对照者以及11名使用铜仿膜透析器进行常规血液透析（150分钟）的儿童进行了PAF、白三烯B4（LTB4）和白三烯C4（LTC4）的研究。在血液透析开始时（0'-毛细血管前）、第一分钟（1'-毛细血管后）以及透析结束后一小时（210'-静脉血）采集血样。与健康对照者相比，0'样本中存在白三烯且PAF水平较高，而1'样本中显著升高，这表明PAF和白三烯的变化可能源于外周白细胞活化。在210'样本中，PAF和白三烯水平降低，但仍高于0'样本中的水平。该研究表明，PAF和LTB4可能是铜仿膜血液透析生物相容性的控制因素，并证明了活化作用持续到下一次透析。
