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红色糖多孢菌A3(2)中负责抗生素合成的途径特异性调控基因redD和actII-ORF4，在体外可由含有σhrdD的RNA聚合酶全酶转录。

redD and actII-ORF4, pathway-specific regulatory genes for antibiotic production in Streptomyces coelicolor A3(2), are transcribed in vitro by an RNA polymerase holoenzyme containing sigma hrdD.

作者信息

Fujii T, Gramajo H C, Takano E, Bibb M J

机构信息

Department of Genetics, Jonn Innes Centre, Norwich Research Park, Colney, United Kingdom.

出版信息

J Bacteriol. 1996 Jun;178(11):3402-5. doi: 10.1128/jb.178.11.3402-3405.1996.

DOI:10.1128/jb.178.11.3402-3405.1996
PMID:8655533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC178105/
Abstract

redD and actII-ORF4, regulatory genes required for synthesis of the antibiotics undecylprodigiosin and actinorhodin by Streptomyces coelicolor A3(2), were transcribed in vitro by an RNA polymerase holoenzyme containing sigma hrdD. Disruption of hrdD had no effect on antibiotic production, indicating that redD and actII-ORF4 are transcribed in vivo by at least one other RNA polymerase holoenzyme. These data provide the first experimental evidence that HrdD can function as a sigma factor.

摘要

红色糖多孢菌A3(2)合成抗生素十一烷基灵菌红素和放线紫红素所需的调控基因redD和actII-ORF4，在体外由含有σhrdD的RNA聚合酶全酶转录。hrdD的破坏对抗生素生产没有影响，这表明redD和actII-ORF4在体内由至少一种其他RNA聚合酶全酶转录。这些数据提供了首个实验证据，证明HrdD可作为一种σ因子发挥作用。

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本文引用的文献

1
The agarase gene (dagA) of Streptomyces coelicolor A3(2): nucleotide sequence and transcriptional analysis.天蓝色链霉菌A3(2)的琼脂糖酶基因(dagA)：核苷酸序列及转录分析
Mol Gen Genet. 1987 Aug;209(1):101-9. doi: 10.1007/BF00329843.
2
Heterogeneity of the principal sigma factor in Escherichia coli: the rpoS gene product, sigma 38, is a second principal sigma factor of RNA polymerase in stationary-phase Escherichia coli.大肠杆菌中主要σ因子的异质性：rpoS基因产物σ38是静止期大肠杆菌中RNA聚合酶的第二个主要σ因子。
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3511-5. doi: 10.1073/pnas.90.8.3511.
3
Bacillus subtilis sporulation: regulation of gene expression and control of morphogenesis.枯草芽孢杆菌的孢子形成：基因表达调控与形态发生控制
Microbiol Rev. 1993 Mar;57(1):1-33. doi: 10.1128/mr.57.1.1-33.1993.
4
Survival of hunger and stress: the role of rpoS in early stationary phase gene regulation in E. coli.饥饿与应激下的存活：rpoS在大肠杆菌稳定早期基因调控中的作用
Cell. 1993 Jan 29;72(2):165-8. doi: 10.1016/0092-8674(93)90655-a.
5
NAD+ binding to the Escherichia coli K(+)-uptake protein TrkA and sequence similarity between TrkA and domains of a family of dehydrogenases suggest a role for NAD+ in bacterial transport.烟酰胺腺嘌呤二核苷酸（NAD+）与大肠杆菌钾离子摄取蛋白TrkA的结合以及TrkA与一类脱氢酶结构域之间的序列相似性表明，NAD+在细菌运输中发挥作用。
Mol Microbiol. 1993 Aug;9(3):533-43. doi: 10.1111/j.1365-2958.1993.tb01714.x.
6
Transcription factor sigma B of Bacillus subtilis controls a large stationary-phase regulon.枯草芽孢杆菌的转录因子σB控制着一个大型的稳定期调控子。
J Bacteriol. 1993 Jul;175(13):3957-63. doi: 10.1128/jb.175.13.3957-3963.1993.
7
In vitro functional characterization of overproduced Escherichia coli katF/rpoS gene product.过量表达的大肠杆菌katF/rpoS基因产物的体外功能特性分析
Biochemistry. 1993 Oct 19;32(41):11112-7. doi: 10.1021/bi00092a021.
8
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Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7573-7. doi: 10.1073/pnas.91.16.7573.
9
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Annu Rev Microbiol. 1994;48:53-80. doi: 10.1146/annurev.mi.48.100194.000413.
10
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Mol Microbiol. 1993 Mar;7(6):837-45. doi: 10.1111/j.1365-2958.1993.tb01174.x.