红色糖多孢菌A3(2)中负责抗生素合成的途径特异性调控基因redD和actII-ORF4，在体外可由含有σhrdD的RNA聚合酶全酶转录。
redD and actII-ORF4, pathway-specific regulatory genes for antibiotic production in Streptomyces coelicolor A3(2), are transcribed in vitro by an RNA polymerase holoenzyme containing sigma hrdD.
作者信息
Fujii T, Gramajo H C, Takano E, Bibb M J
机构信息
Department of Genetics, Jonn Innes Centre, Norwich Research Park, Colney, United Kingdom.
出版信息
J Bacteriol. 1996 Jun;178(11):3402-5. doi: 10.1128/jb.178.11.3402-3405.1996.
Abstract
redD and actII-ORF4, regulatory genes required for synthesis of the antibiotics undecylprodigiosin and actinorhodin by Streptomyces coelicolor A3(2), were transcribed in vitro by an RNA polymerase holoenzyme containing sigma hrdD. Disruption of hrdD had no effect on antibiotic production, indicating that redD and actII-ORF4 are transcribed in vivo by at least one other RNA polymerase holoenzyme. These data provide the first experimental evidence that HrdD can function as a sigma factor.
摘要
红色糖多孢菌A3(2)合成抗生素十一烷基灵菌红素和放线紫红素所需的调控基因redD和actII-ORF4，在体外由含有σhrdD的RNA聚合酶全酶转录。hrdD的破坏对抗生素生产没有影响，这表明redD和actII-ORF4在体内由至少一种其他RNA聚合酶全酶转录。这些数据提供了首个实验证据，证明HrdD可作为一种σ因子发挥作用。
相似文献
1
redD and actII-ORF4, pathway-specific regulatory genes for antibiotic production in Streptomyces coelicolor A3(2), are transcribed in vitro by an RNA polymerase holoenzyme containing sigma hrdD.红色糖多孢菌A3(2)中负责抗生素合成的途径特异性调控基因redD和actII-ORF4，在体外可由含有σhrdD的RNA聚合酶全酶转录。
J Bacteriol. 1996 Jun;178(11):3402-5. doi: 10.1128/jb.178.11.3402-3405.1996.
2
Differential production of two antibiotics of Streptomyces coelicolor A3(2), actinorhodin and undecylprodigiosin, upon salt stress conditions.天蓝色链霉菌A3(2)在盐胁迫条件下两种抗生素放线紫红素和十一烷基灵菌红素的差异产生
Arch Microbiol. 2004 May;181(5):384-9. doi: 10.1007/s00203-004-0669-1. Epub 2004 Mar 31.
3
A single amino acid substitution in region 1.2 of the principal sigma factor of Streptomyces coelicolor A3(2) results in pleiotropic loss of antibiotic production.天蓝色链霉菌A3(2)主要σ因子1.2区域的单个氨基酸替换导致抗生素生产的多效性丧失。
Mol Microbiol. 2000 Sep;37(5):995-1004. doi: 10.1046/j.1365-2958.2000.02022.x.
4
afsR is a pleiotropic but conditionally required regulatory gene for antibiotic production in Streptomyces coelicolor A3(2).afsR是天蓝色链霉菌A3(2)中抗生素生产的一个多效性但有条件必需的调控基因。
Mol Microbiol. 1996 Jul;21(2):385-96. doi: 10.1046/j.1365-2958.1996.6491364.x.
5
Activation of antibiotic biosynthesis by specified mutations in the rpoB gene (encoding the RNA polymerase beta subunit) of Streptomyces lividans.通过淡紫链霉菌rpoB基因（编码RNA聚合酶β亚基）中的特定突变激活抗生素生物合成。
J Bacteriol. 2002 Jul;184(14):3984-91. doi: 10.1128/JB.184.14.3984-3991.2002.
6
Identification of sigma factors for growth phase-related promoter selectivity of RNA polymerases from Streptomyces coelicolor A3(2).天蓝色链霉菌A3(2)中与生长阶段相关的RNA聚合酶启动子选择性的σ因子鉴定
Nucleic Acids Res. 1997 Jul 1;25(13):2566-73. doi: 10.1093/nar/25.13.2566.
7
Involvement of AlpV, a new member of the Streptomyces antibiotic regulatory protein family, in regulation of the duplicated type II polyketide synthase alp gene cluster in Streptomyces ambofaciens.链霉菌抗生素调节蛋白家族新成员AlpV参与调控产二素链霉菌中重复的II型聚酮合酶alp基因簇。
J Bacteriol. 2005 Apr;187(7):2491-500. doi: 10.1128/JB.187.7.2491-2500.2005.
8
Induction of ppGpp synthesis in Streptomyces coelicolor A3(2) grown under conditions of nutritional sufficiency elicits actII-ORF4 transcription and actinorhodin biosynthesis.在营养充足条件下生长的天蓝色链霉菌A3(2)中诱导ppGpp合成会引发actII-ORF4转录和放线紫红素生物合成。
Mol Microbiol. 2001 Jan;39(1):136-44. doi: 10.1046/j.1365-2958.2001.02221.x.
9
abaA, a new pleiotropic regulatory locus for antibiotic production in Streptomyces coelicolor.abaA，天蓝色链霉菌中一个新的抗生素生产多效性调控基因座。
J Bacteriol. 1992 May;174(9):2958-67. doi: 10.1128/jb.174.9.2958-2967.1992.
10
bldA dependence of undecylprodigiosin production in Streptomyces coelicolor A3(2) involves a pathway-specific regulatory cascade.天蓝色链霉菌A3(2)中十一烷基灵菌红素产生对bldA的依赖性涉及一条途径特异性调控级联反应。
J Bacteriol. 1997 Feb;179(3):627-33. doi: 10.1128/jb.179.3.627-633.1997.
引用本文的文献
1
Influence of Cluster-Situated Regulator PteF in Filipin Biosynthetic Cluster on Avermectin Biosynthesis in .簇状调控因子PteF在菲律宾菌素生物合成簇中对阿维菌素生物合成的影响 。
你提供的原文似乎不完整，句末的“in.”后面缺少具体内容。
Biology (Basel). 2024 May 15;13(5):344. doi: 10.3390/biology13050344.
2
The LysR family transcriptional regulator ORF-L16 regulates spinosad biosynthesis in .LysR家族转录调节因子ORF-L16调控多杀菌素的生物合成。
Synth Syst Biotechnol. 2024 May 10;9(4):609-617. doi: 10.1016/j.synbio.2024.05.001. eCollection 2024 Dec.
3
Enhanced protein secretion in reduced genome strains of Streptomyces lividans.链霉菌属中基因组减少菌株的蛋白质分泌增强。
Microb Cell Fact. 2024 Jan 5;23(1):13. doi: 10.1186/s12934-023-02269-x.
4
RIViT-seq enables systematic identification of regulons of transcriptional machineries.RIViT-seq 能够系统地识别转录机器的调控子。
Nat Commun. 2022 Jun 17;13(1):3502. doi: 10.1038/s41467-022-31191-w.
5
Regulatory Control of Rishirilide(s) Biosynthesis in .里氏内酯生物合成的调控控制
Microorganisms. 2021 Feb 12;9(2):374. doi: 10.3390/microorganisms9020374.
6
DNA mapping and kinetic modeling of the HrdB regulon in Streptomyces coelicolor.链霉菌 HrdB 调控组的 DNA 图谱和动力学建模。
Nucleic Acids Res. 2019 Jan 25;47(2):621-633. doi: 10.1093/nar/gky1018.
7
Connecting Metabolic Pathways: Sigma Factors in spp.连接代谢途径：[具体物种名称]中的σ因子 （原文中“spp.”表述有误，推测应该是某一具体物种的复数形式，这里按正确理解的格式翻译，但原英文表述不完整）
Front Microbiol. 2017 Dec 19;8:2546. doi: 10.3389/fmicb.2017.02546. eCollection 2017.
8
Biomass-derived molecules modulate the behavior of Streptomyces coelicolor for antibiotic production.生物质衍生分子调节天蓝色链霉菌产生抗生素的行为。
3 Biotech. 2016 Dec;6(2):223. doi: 10.1007/s13205-016-0539-y. Epub 2016 Oct 15.
9
The CCTL (Cpf1-assisted Cutting and Taq DNA ligase-assisted Ligation) method for efficient editing of large DNA constructs in vitro.用于体外高效编辑大型DNA构建体的CCTL（Cpf1辅助切割和Taq DNA连接酶辅助连接）方法。
Nucleic Acids Res. 2017 May 19;45(9):e74. doi: 10.1093/nar/gkx018.
10
Acidic pH shock induces the expressions of a wide range of stress-response genes.酸性pH冲击诱导多种应激反应基因的表达。
BMC Genomics. 2008 Dec 16;9:604. doi: 10.1186/1471-2164-9-604.
本文引用的文献
1
The agarase gene (dagA) of Streptomyces coelicolor A3(2): nucleotide sequence and transcriptional analysis.天蓝色链霉菌A3(2)的琼脂糖酶基因(dagA)：核苷酸序列及转录分析
Mol Gen Genet. 1987 Aug;209(1):101-9. doi: 10.1007/BF00329843.
2
Heterogeneity of the principal sigma factor in Escherichia coli: the rpoS gene product, sigma 38, is a second principal sigma factor of RNA polymerase in stationary-phase Escherichia coli.大肠杆菌中主要σ因子的异质性：rpoS基因产物σ38是静止期大肠杆菌中RNA聚合酶的第二个主要σ因子。
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3511-5. doi: 10.1073/pnas.90.8.3511.
3
Bacillus subtilis sporulation: regulation of gene expression and control of morphogenesis.枯草芽孢杆菌的孢子形成：基因表达调控与形态发生控制
Microbiol Rev. 1993 Mar;57(1):1-33. doi: 10.1128/mr.57.1.1-33.1993.
4
Survival of hunger and stress: the role of rpoS in early stationary phase gene regulation in E. coli.饥饿与应激下的存活：rpoS在大肠杆菌稳定早期基因调控中的作用
Cell. 1993 Jan 29;72(2):165-8. doi: 10.1016/0092-8674(93)90655-a.
5
NAD+ binding to the Escherichia coli K(+)-uptake protein TrkA and sequence similarity between TrkA and domains of a family of dehydrogenases suggest a role for NAD+ in bacterial transport.烟酰胺腺嘌呤二核苷酸（NAD+）与大肠杆菌钾离子摄取蛋白TrkA的结合以及TrkA与一类脱氢酶结构域之间的序列相似性表明，NAD+在细菌运输中发挥作用。
Mol Microbiol. 1993 Aug;9(3):533-43. doi: 10.1111/j.1365-2958.1993.tb01714.x.
6
Transcription factor sigma B of Bacillus subtilis controls a large stationary-phase regulon.枯草芽孢杆菌的转录因子σB控制着一个大型的稳定期调控子。
J Bacteriol. 1993 Jul;175(13):3957-63. doi: 10.1128/jb.175.13.3957-3963.1993.
7
In vitro functional characterization of overproduced Escherichia coli katF/rpoS gene product.过量表达的大肠杆菌katF/rpoS基因产物的体外功能特性分析
Biochemistry. 1993 Oct 19;32(41):11112-7. doi: 10.1021/bi00092a021.
8
Analysis of the Streptomyces coelicolor sigE gene reveals the existence of a subfamily of eubacterial RNA polymerase sigma factors involved in the regulation of extracytoplasmic functions.天蓝色链霉菌sigE基因分析揭示了参与胞质外功能调控的真细菌RNA聚合酶σ因子亚家族的存在。
Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7573-7. doi: 10.1073/pnas.91.16.7573.
9
The role of the sigma factor sigma S (KatF) in bacterial global regulation.σ因子σS（KatF）在细菌全局调控中的作用。
Annu Rev Microbiol. 1994;48:53-80. doi: 10.1146/annurev.mi.48.100194.000413.
10
Stationary-phase production of the antibiotic actinorhodin in Streptomyces coelicolor A3(2) is transcriptionally regulated.天蓝色链霉菌A3(2)中抗生素放线紫红素的稳定期产生受到转录调控。
Mol Microbiol. 1993 Mar;7(6):837-45. doi: 10.1111/j.1365-2958.1993.tb01174.x.
Zotero 插件