Lewis J D, Gunderson S I, Mattaj I W
Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany.
J Cell Sci Suppl. 1995;19:13-9. doi: 10.1242/jcs.1995.supplement_19.2.
The 5' cap structure of RNA polymerase II transcripts and the poly(A) tail found at the 3' end of most mRNAs have been demonstrated to play multiple roles in gene expression and its regulation. In the first part of this review we will concentrate on the role played by the cap in pre-mRNA splicing and how it may contribute to efficient and specific substrate recognition. In the second half, we will discuss the roles that polyadenylation has been demonstrated to play in RNA metabolism and will concentrate in particular on an elegant mechanism where regulation of polyadenylation is used to control gene expression.
RNA聚合酶II转录本的5'帽结构以及大多数mRNA 3'端的聚腺苷酸尾巴已被证明在基因表达及其调控中发挥多种作用。在本综述的第一部分，我们将专注于帽在mRNA前体剪接中所起的作用，以及它如何有助于高效且特异性地识别底物。在第二部分，我们将讨论聚腺苷酸化在RNA代谢中已被证明所起的作用，并将特别关注一种精妙的机制，即利用聚腺苷酸化的调控来控制基因表达。
