De Jong M, Coppee M C, De Halleux F, Deckers C, Maisin H
Neoplasma. 1977;24:139-46.
The effects of Azathioprine (AZA) on the carcinogenesis with 3-Methylcholanthrene (MC) are described. When AZA is given before MC, there is a shortened tumor latency period. When AZA treatment followed MC injection a lengthened latency period was observed. When AZA treatment is given both before and after MC injection, intermediate results were observed. It is concluded that the action of AZA treatment on tumor development depends on the time relationship between this treatment and the injection of the carcinogen. In particular, it is suggested that to obtain an enhancing effect on tumor development, probably by immunosuppression, AZA must be effective at the time or shortly after administration of the carcinogen. When AZA is administered later, an inhibition of tumor development, probably a cytostatic effect becomes prominent.
描述了硫唑嘌呤（AZA）对3-甲基胆蒽（MC）致癌作用的影响。当在给予MC之前给予AZA时，肿瘤潜伏期缩短。当在注射MC后进行AZA治疗时，观察到潜伏期延长。当在注射MC之前和之后都给予AZA治疗时，观察到的是中间结果。得出的结论是，AZA治疗对肿瘤发展的作用取决于该治疗与致癌物注射之间的时间关系。特别是，有人提出，为了对肿瘤发展获得增强作用，可能是通过免疫抑制作用，AZA必须在给予致癌物时或之后不久发挥作用。当稍后给予AZA时，对肿瘤发展的抑制作用，可能是一种细胞生长抑制作用就会变得明显。
