Horta J L, Fernández J G, de León B S, Cortés-Gallegos V
Obstet Gynecol. 1977 Jun;49(6):705-8.
Plasma levels of progesterone were measured during the luteal phase in 10 of 15 women with clinical histories of at least three spontaneous abortions in the last three gestations, and in 15 healthy nonpregnant women during the same phase of the ovarian cycle. Progesterone values found in the women with habitual abortion were lower (P less than 0.05-0.005) than in the nonpregnant group almost throughout the period of observation. The habitually aborting women who became pregnant again aborted between the seventh and 12th weeks. Their progesterone concentrations were less than 6 ng/ml, 48-72 hours before vaginal bleeding or abortion. These values were compared with those found during the first 12 weeks in normal pregnancy (P less than 0.001). The results suggest a useful method of evaluating the treatment of habitual abortion.
对15名在过去三次妊娠中至少有三次自然流产临床病史的女性中的10名，在黄体期测量其血浆孕酮水平，并在15名健康非妊娠女性的卵巢周期同一阶段进行测量。在几乎整个观察期内，习惯性流产女性的孕酮值低于非妊娠组（P小于0.05 - 0.005）。再次怀孕的习惯性流产女性在第7至12周期间流产。在阴道出血或流产前48 - 72小时，她们的孕酮浓度低于6 ng/ml。这些值与正常妊娠前12周的值进行比较（P小于0.001）。结果提示了一种评估习惯性流产治疗效果的有用方法。
