Chung T, Hoffer F A, Burrows P E, Paltiel H J
Department of Radiology, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Pediatr Radiol. 1996;26(5):341-8. doi: 10.1007/BF01395711.
The purpose of this study was to describe the appearance on magnetic resonance (MR) imaging of hepatic hemangioma, and how the appearance changes in infants who have received interferon alpha-2a (IFN) treatment. We retrospectively studied 16 MR examinations in seven infants (mean age 3.2 months; range 5 days to 13 months) who were symptomatic with hepatic hemangiomas. Five of these seven patients had MR examinations both before and after treatment with IFN. In six of the seven patients, the hepatic hemangiomas were multicentric; they were usually discrete, well-defined nodules, best seen on T2-weighted images as high intensity lesions. One patient had a large solitary heterogeneous lesion. They all exhibited fast flow (seen as flow voids on spin-echo images and high signal intensity structures on gradient-recalled echo images) and enlarged hepatic arteries and veins. There was enlargement of the proximal abdominal aorta with distal tapering. Treatment was followed by accelerated regression of the hemangiomas in size and number and variable shrinkage of the enlarged vessels. As the tumor nodules regressed, they were replaced by normal-appearing hepatic parenchyma; neither fat nor fibrosis was detected by MR imaging.
本研究的目的是描述肝血管瘤的磁共振（MR）成像表现，以及接受α-2a干扰素（IFN）治疗的婴儿其表现如何变化。我们回顾性研究了7例有肝血管瘤症状的婴儿（平均年龄3.2个月；范围5天至13个月）的16次MR检查。这7例患者中有5例在IFN治疗前后均进行了MR检查。7例患者中有6例的肝血管瘤为多中心性；它们通常为散在、边界清晰的结节，在T2加权图像上最易显示为高信号病变。1例患者有一个大的孤立性不均匀病变。它们均表现为血流快速（在自旋回波图像上表现为血流空信号，在梯度回波图像上表现为高信号强度结构）以及肝动脉和静脉增粗。腹主动脉近端增粗，远端变细。治疗后，血管瘤在大小和数量上加速消退，增粗的血管也有不同程度的缩小。随着肿瘤结节的消退，它们被外观正常的肝实质所取代；MR成像未检测到脂肪或纤维化。
