[干燥波尔多提取物对健康志愿者口腔至盲肠肠道转运的影响]
[Effect of a dry boldo extract on oro-cecal intestinal transit in healthy volunteers].
作者信息
Gotteland M, Espinoza J, Cassels B, Speisky H
机构信息
Unidad de Gastroenterología, INTA, Santiago de Chile.
出版信息
Rev Med Chil. 1995 Aug;123(8):955-60.
BACKGROUND
Boldo (Peumus boldus Molina) is a widely used medicinal plant. However, its physiological effects are not well known. Recent studies in animals showed that certain components of boldo relax smooth muscle and prolong intestinal transit.
AIM
To assess the effects of a dry boldo extract on oro cecal transit time in normal humans.
SUBJECTS AND METHODS
Twelve volunteers received 2.5 g of a dry boldo extract or a placebo (glucose) during two successive periods of four days. On the fourth day, 20 g of lactulose were administered and breath hydrogen was collected every 15 min. Oro cecal transit time was defined as the time in which breath hydrogen increased by 20 ppm over the fasting level.
RESULTS
Oro cecal transit time was larger after dry boldo extract administration, compared to placebo (112.5 +/- 15.4 and 87 +/- 11.8 min respectively, paired t p < 0.05).
CONCLUSIONS
Dry boldo extract prolongs oro cecal transit time, a possible explanation for its medicinal use.
背景
波尔多树（Peumus boldus Molina）是一种广泛使用的药用植物。然而，其生理作用尚不为人所知。最近在动物身上的研究表明，波尔多树的某些成分可使平滑肌松弛并延长肠道传输时间。
目的
评估干燥波尔多树提取物对正常人体口腔至盲肠传输时间的影响。
对象与方法
12名志愿者在两个连续的四天周期内分别服用2.5克干燥波尔多树提取物或安慰剂（葡萄糖）。在第四天，给予20克乳果糖，并每隔15分钟收集呼出的氢气。口腔至盲肠传输时间定义为呼出氢气比空腹水平增加20 ppm的时间。
结果
与安慰剂相比，服用干燥波尔多树提取物后的口腔至盲肠传输时间更长（分别为112.5 +/- 15.4分钟和87 +/- 11.8分钟，配对t检验p < 0.05）。
结论
干燥波尔多树提取物可延长口腔至盲肠传输时间，这可能是其药用的一种解释。
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