睾丸内注射催产素对未成熟大鼠睾丸类固醇生成的影响。

Effect of intratesticular administration of oxytocin on testicular steroidogenesis in immature rats.

作者信息

Gerendai I, Csernus V

机构信息

2nd Department of Anatomy, Semmelweis University Medical School, Budapest, Hungary.

出版信息

Andrologia. 1995 Sep-Oct;27(5):291-7. doi: 10.1111/j.1439-0272.1995.tb01107.x.

DOI:10.1111/j.1439-0272.1995.tb01107.x

PMID:8659708

Abstract

The possible physiological role of testicular oxytocin in testicular steroidogenesis was studied in immature rats. In 5-, 9-, and 25-day-old animals one of the testes was injected with 20, 50, and 200 ng of oxytocin, respectively, then the contralateral gonad was removed. Rats were killed 1 h, 1 day, or 7 days post-surgery. In each age group studied intratesticular injection of oxytocin resulted in a significant increase in basal testosterone secretion in vitro and/or serum testosterone concentration. Data indicate that in immature rats oxytocin of testicular origin might act as a local stimulator of steroidogenesis.

摘要

在未成熟大鼠中研究了睾丸催产素在睾丸类固醇生成中可能的生理作用。对5日龄、9日龄和25日龄的动物，分别向一侧睾丸注射20纳克、50纳克和200纳克催产素，然后切除对侧性腺。术后1小时、1天或7天处死大鼠。在所研究的每个年龄组中，睾丸内注射催产素均导致体外基础睾酮分泌和/或血清睾酮浓度显著增加。数据表明，在未成熟大鼠中，睾丸来源的催产素可能作为类固醇生成的局部刺激物。