Akberova S I, Leont'eva N A, Stroeva O G, Galegov G A
Antibiot Khimioter. 1995 Oct;40(10):25-9.
The effect of para-amino benzoic acid (PABA) on the virus of Herpes simplex (VHS-1, strain L2) was studied and it was shown to be active in vitro and in vivo. The action of PABA was virucidal in the culture of the cell-free virus-containing material. It lowered the death rate of the laboratory mice with experimental herpetic encephalitis (intraperitoneal contamination) at the average by 40 per cent and increased the mean life-span of the animals significantly decreasing the virus titre in the mouse brain. PABA was not toxic with respect to the Vero cells thus not preventing the virus-induced cytopathic effect in the cultures. However, PABA showed high ability to potentiate the antiherpetic action of acyclovir (Zovirax, acycloguanosine) in the infected cultures when acyclovir was used in inactive concentrations.
研究了对氨基苯甲酸（PABA）对单纯疱疹病毒（VHS-1，L2株）的作用，结果表明其在体外和体内均具有活性。PABA对不含细胞的含病毒物质培养物具有杀病毒作用。它使患有实验性疱疹性脑炎（腹腔感染）的实验小鼠的死亡率平均降低了40%，并显著延长了动物的平均寿命，同时降低了小鼠脑中的病毒滴度。PABA对Vero细胞无毒，因此不会阻止培养物中病毒诱导的细胞病变效应。然而，当阿昔洛韦以无活性浓度使用时，PABA在受感染的培养物中显示出增强阿昔洛韦（佐韦拉克斯，阿昔洛韦）抗疱疹作用的高能力。
