Kalyanaraman B
Biophysics Research Institute, Medical College of Wisconsin, Milwaukee 53226-06059, USA.
Biochem Soc Symp. 1995;61:55-63. doi: 10.1042/bss0610055.
Thiyl radicals are formed from one-electron oxidation of thiols. Thiyl radicals participate in a number of reactions including electron transfer, hydrogen abstraction and addition reactions with several biological constituents and xenobiotics. Thiyl radicals can be detected by optical spectroscopy or by electron spin resonance (ESR) spectroscopy. Thiyl radicals appear to play a role in the nitrosylation of thiols and protein thiols. The exact mechanism of thiol-induced enhancement of oxidative modification of low-density lipoprotein remains questionable. The proposed role of thiyl radicals in lipid peroxidation needs to be re-examined. It has been proposed that thiyl radicals are detoxified by superoxide dismutase in mammalian cells and by a thiol-specific enzyme in bacterial systems. We propose that thiols or protein thiols act as potent antioxidants in radical-induced damage via formation of thiyl radicals.
硫自由基由硫醇的单电子氧化形成。硫自由基参与许多反应，包括电子转移、氢原子提取以及与多种生物成分和外源性物质的加成反应。硫自由基可通过光学光谱法或电子自旋共振（ESR）光谱法检测。硫自由基似乎在硫醇和蛋白质硫醇的亚硝基化中起作用。硫醇诱导的低密度脂蛋白氧化修饰增强的确切机制仍存在疑问。硫自由基在脂质过氧化中所提出的作用需要重新审视。有人提出，硫自由基在哺乳动物细胞中由超氧化物歧化酶解毒，在细菌系统中由一种硫醇特异性酶解毒。我们提出，硫醇或蛋白质硫醇通过形成硫自由基在自由基诱导的损伤中作为有效的抗氧化剂。
